特定益生菌可改善健康成年人的压力和焦虑
创作:szx 审核:szx 01月07日
  • 120名健康成年人随机均分为2组,每日分别补充Lpc-37或安慰剂,持续干预5周;
  • 主要终点为Trier社会压力测试(TSST)下的心率,次要终点为生物标志物及自我评定量表;
  • Lpc-37未能显著改善受试者的主要终点,但可显著减少TSST下低度慢性压力(LCS)受试者的心率增加值;
  • Lpc-37可显著降低受试者的感知压力,并可减少LCS受试者在TSST下的精疲力竭,恢复LCS受试者晚上8点的皮质醇水平,增强HCS受试者的自感健康及睡眠恢复。
主编推荐语
szx
有临床证据表明,益生菌可能影响应激反应及情绪。Neurobiology of Stress上发表的一项随机双盲安慰剂对照临床试验,在120名健康成年人(18-45岁)中,每日补充Lacticaseibacillus paracasei Lpc-37® (Lpc-37) 可降低受试者的感知压力,而Lpc对其它压力及焦虑相关指标的改善作用受到性别及慢性压力程度等因素的影响。
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Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)

Lacticaseibacillus paracasei Lpc-37®改善健康成年人的压力及焦虑的心理及生理标志物:一项随机双盲安慰剂对照及平行临床试验

10.1016/j.ynstr.2020.100277

2020-11-24, Article

Abstract & Authors:展开

Abstract:收起
Chronic stress is a risk-factor for the development of mood and stress-related disorders. Clinical evidence indicates that probiotics can influence the stress response and mood. The Sisu study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could modulate stress, mood and well-being. Prior to a two-week run-in period, 120 healthy adults (18-45 y) were stratified for sex and chronic stress and randomized to either 1.75 × 1010 colony forming units (CFU) of Lpc-37 or placebo (1:1) per day for 5 weeks. The primary objective was the effect of Lpc-37 on heart rate (HR) in response to the Trier Social Stress Test (TSST). Secondary objectives were assessed by biomarkers and self-report scales over the study. The primary hypothesis was not met in either the Intention-to-Treat (ITT) or Per Protocol (PP) population, but Lpc-37 reduced the increase in HR in participants with low chronic stress (LCS) and increased HR in participants with high chronic stress (HCS) during the TSST. Supporting significant efficacy in the PP population (n = 113), Lpc-37 reduced perceived stress following intervention. More significant effects were identified within the subgroups where Lpc-37 reduced exhaustion during the TSST and normalized cortisol levels at 8pm in participants with LCS, reduced perceived stress also in females, and increased perceived health and sleep-related recovery in participants with HCS. Adverse events (AEs) were similar between groups, there were no severe AEs, and vital signs remained unchanged. Overall, Lpc-37 reduced perceived stress compared to placebo. Other beneficial effects within biomarkers related to stress indicate that the effects of Lpc-37 may be differentially dependent on sex and chronic stress.

First Authors:
Elaine Patterson

Correspondence Authors:
Elaine Patterson

All Authors:
Elaine Patterson,Síle M Griffin,Alvin Ibarra,Emilia Ellsiepen,Juliane Hellhammer

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