Cell:肠炎部位为何会有脂肪增生?
  • 克罗恩病患者肠系膜脂肪组织(MAT)的爬行脂肪(CrF)中,存在一群从肠道移位出来的粘膜相关微生物,能在CrF中存活;
  • 无害梭菌是其中最常见的,在粘膜和脂肪中存在菌株变化,可能对脂质环境有偏好性;
  • 悉生小鼠中,无害梭菌能移位至MAT,引起MAT扩张;
  • CrF的特征为促纤维化和促脂肪生成,且有活跃的微生物免疫监视;
  • 无害梭菌能增加促纤维化的M2巨噬细胞,从而可能通过刺激组织重塑形成脂肪组织屏障,以防止细菌从肠道向全身扩散。
主编推荐语
mildbreeze
“爬行脂肪”(creeping fat)是指克罗恩病患者炎症/纤维化肠段周围肥大的肠系膜脂肪组织。Cell最新发表的一项研究表明,在克罗恩病患者中,这种“爬行脂肪”的现象其实是一种人体的保护性反应。这些增生的肠系膜脂肪组织在移位出来的无害梭菌(Clostridium innocuum)等肠道细菌的刺激下,“爬”向有肠屏障损伤的位点,从而“堵上”肠道的“漏洞”,阻止潜在的有害细菌抗原顺着屏障损伤从肠道中扩散出来。
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Cell [IF:38.637]

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

可存活的肠道菌群向肠系膜脂肪的移位,驱动了人体的“爬行脂肪”形成

10.1016/j.cell.2020.09.009

2020-09-28, Article

Abstract & Authors:展开

Abstract:收起
A mysterious feature of Crohn’s disease (CD) is the extra-intestinal manifestation of “creeping fat” (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for CrF development. We discovered a subset of mucosal-associated gut bacteria that consistently translocated and remained viable in CrF in CD ileal surgical resections, and identified Clostridium innocuum as a signature of this consortium with strain variation between mucosal and adipose isolates, suggesting preference for lipid-rich environments. Single-cell RNA sequencing characterized CrF as both pro-fibrotic and pro-adipogenic with a rich milieu of activated immune cells responding to microbial stimuli, which we confirm in gnotobiotic mice colonized with C. innocuum. Ex vivo validation of expression patterns suggests C. innocuum stimulates tissue remodeling via M2 macrophages, leading to an adipose tissue barrier that serves to prevent systemic dissemination of bacteria.

First Authors:
Anthony Martin

Correspondence Authors:
Suzanne Devkota

All Authors:
Anthony Martin,Gregory D Sepich-Poore,Baochen Shi,Yizhou Wang,Kenneth Gouin,Gregory Humphrey,Karenina Sanders,Yasiru Ratnayake,Kelvin SL Chan,Gustaf Hendrick,JR Caldera,Christian Arias,Jacob E Moskowitz,Shannan J Ho Sui,Shaohong Yang,David Underhill,Matthew J Brady,Simon Knott,Kelly Kaihara,Michael J Steinbaugh,Huiying Li,Dermot PB McGovern,Rob Knight,Phillip Fleshner,Suzanne Devkota

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肠道菌群与代谢微信公众号

Cell|肠道菌群向肠系膜脂肪的易位促进人类爬行脂肪的形成

聂启兴,2021-11-14

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