合生制剂可改善老年人的多项健康指标
创作:szx 审核:szx 2020年05月21日
  • 60名老年人随机分为2组,干预组每日摄入合生制剂(含有植物乳杆菌PBS067、嗜酸乳杆菌PBS066、罗伊氏乳杆菌PBS072、菊粉与低聚果糖),对照组每日摄入安慰剂;
  • 在2个月的干预结束后,与干预前及对照组相比,干预组的腰围、空腹血浆胰岛素、总胆固醇、HDL胆固醇、非HDL胆固醇、甘油三酯、LDL胆固醇、高密度C反应蛋白、血清TNF-α水平、动脉血压及空腹血糖均得到显著改善;
  • 相比于对照组,干预组的内脏肥胖指数得到了更多的改善。
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szx
《European Journal of Nutrition》上发表的一项RCT研究,在60名老年人中进行为期2个月的干预,发现每日补充合生制剂(含有3种乳杆菌属菌株及活性益生元——菊粉与低聚果糖)可显著改善多项心血管疾病风险及代谢综合征相关指标。
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Impact of a short-term synbiotic supplementation on metabolic syndrome and systemic inflammation in elderly patients: a randomized placebo-controlled clinical trial

短期补充合生制剂对老年人的代谢综合征与系统性炎症的影响:一项随机安慰剂对照临床试验

10.1007/s00394-020-02271-8

2020-05-16, Article

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Purpose: The connection between gut microbiota imbalance, inflammation and its role in the pathogenesis of metabolic syndrome (MetS) clustering factors has been increasingly recognized. However, data on the efficacy of probiotics supplementation on MetS components are few and almost lacking in the elderly. To address this issue, we conducted a randomized, double-blind, placebo-controlled, parallel-group, clinical study on a large sample of MetS elderly patients.
Methods: After 14 days of diet and physical activity standardization, 60 elderly patients were randomized to treatment with a synbiotic formula of Lactobacillus plantarum PBS067, Lactobacillus acidophilus PBS066 and Lactobacillus reuteri PBS072 with active prebiotics or placebo. Patients were evaluated anamnestically and by the execution of a physical examination and laboratory and haemodynamic analyses at the baseline and after 60 days of treatment. At enrollment and at the end of the trial, all enrolled patients complete the EuroQol-5 Dimension (EQ-5D) questionnaire.
Results: Through the 2-month period of treatment, patients who received active treatment experienced a statistically significant improvement in waist circumference and in fasting plasma insulin, total cholesterol, high-density lipoprotein cholesterol, non-HDL-C, triglycerides (TG), low-density lipoprotein cholesterol, high-sensitivity C-reactive protein and tumor necrosis factor alpha serum levels, compared both to the baseline and the control group. Visceral adiposity index improvement in the synbiotic treatment group was significantly greater than in placebo group. Compared to baseline, treatment with synbiotics also significantly reduced mean arterial pressure and fasting plasma glucose. All treatment groups demonstrated a significant decrease in TG. TG reduction in the synbiotic group was significantly greater than in the control group. The EQ-5D VAS questionnaire significantly improved only in probiotics-treated subjects.
Conclusion: Treatment with a synbiotic formula of L. plantarum PBS067, L. acidophilus PBS066 and L. reuteri PBS072 with active prebiotics decreased MetS syndrome prevalence, several cardiovascular risk factors and markers of insulin resistance in elderly patients.

First Authors:
Arrigo F G Cicero

Correspondence Authors:
Arrigo F G Cicero

All Authors:
Arrigo F G Cicero,Federica Fogacci,Marilisa Bove,Marina Giovannini,Claudio Borghi

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