酒精滥用中的肠脑轴(综述)
  • 酒精使用障碍与社会认知和情绪功能的缺陷相关;
  • 酒精滥用可促进肠漏和肠道菌群失调,通过免疫炎症和多种肠脑轴途径,增加大脑的神经损伤;
  • 额叶-边缘系统是酒精滥用、外周炎症和肠道菌群共同影响的大脑区域,其异常可引发情感失调;
  • 酒精相关的肠道菌群失调和社会认知缺陷,可能通过免疫情感途径,加速从酗酒向酒精成瘾的转变;
  • 青少年时期,菌群-肠-脑轴仍在发育,因而青少年更易受到酗酒的不良影响。
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mildbreeze
Molecular Psychiatry近期发表综述文章,提出了一个整合了肠道菌群、神经免疫和情绪调控的生物学框架,来阐释情绪失调和饮酒相关的菌群失调如何加速成瘾的恶性循环。
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A biological framework for emotional dysregulation in alcohol misuse: from gut to brain

酒精滥用中情绪失调的生物学框架:从肠至脑

10.1038/s41380-020-00970-6

2020-12-07, Review

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Alcohol use disorder (AUD) has been associated with impairments in social and emotional cognition that play a crucial role in the development and maintenance of addiction. Repeated alcohol intoxications trigger inflammatory processes and sensitise the immune system. In addition, emerging data point to perturbations in the gut microbiome as a key regulator of the inflammatory cascade in AUD. Inflammation and social cognition are potent modulators of one another. At the same time, accumulating evidence implicates the gut microbiome in shaping emotional and social cognition, suggesting the possibility of a common underlying loop of crucial importance for addiction. Here we propose an integrative microbiome neuro-immuno-affective framework of how emotional dysregulation and alcohol-related microbiome dysbiosis could accelerate the cycle of addiction. We outline the overlapping effects of chronic alcohol use, inflammation and microbiome alterations on the fronto-limbic circuitry as a convergence hub for emotional dysregulation. We discuss the interdependent relationship of social cognition, immunity and the microbiome in relation to alcohol misuse- from binge drinking to addiction. In addition, we emphasise adolescence as a sensitive period for the confluence of alcohol harmful effects and emotional dysregulation in the developing gut–brain axis.

First Authors:
Carina Carbia

Correspondence Authors:
John F Cryan

All Authors:
Carina Carbia,Séverine Lannoy,Pierre Maurage,Eduardo López-Caneda,Kenneth J O Riordan,Timothy G Dinan,John F Cryan

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