Nature子刊:老了再开始热量限制,效果可能有限
  • 长期饮食限制(DR,减少40%热量摄入)或任意进食(AL)的小鼠,在老年后(24个月)交换饮食方式;
  • 原DR小鼠改为AL饮食(DRAL)后死亡率升高,而从AL改为DR(ALDR)的小鼠中,DR延长寿命的效果有限;
  • 小鼠脂肪组织(尤其白色脂肪)的基因表达和代谢会对长期AL产生“记忆”,这削弱了老年后DR对脂代谢和线粒体的影响;
  • 长期AL还使老化脂肪前体细胞呈现促炎特征;
  • DRAL小鼠的基因表达和代谢,对之前的DR只有很弱的“记忆”。
主编推荐语
mildbreeze
成年期的饮食限制(DR,在不引起营养不良的情况下减少进食的热量),在多种动物模型中都展现出改善代谢健康和延长寿命的作用。那么如果从老年时再开始DR,是否还会有这些好处呢?Nature Metabolism近期发表的一项研究发现,长期任意进食的小鼠,其脂肪组织的基因表达和代谢情况会形成“记忆”,从而削弱了老年后开始热量限制的益处。
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A nutritional memory effect counteracts the benefits of dietary restriction in old mice

营养记忆效应抵消了饮食限制对老年小鼠的好处

10.1038/s42255-019-0121-0

2019-10-21, Article

Abstract & Authors:展开

Abstract:收起
Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR in mammals is still effective when applied for the first time at old age remains elusive. Here, we report results of a late-life DR-switch experiment using 800 mice. Female mice aged 24 months were switched from an ad libitum (AL) diet to DR or vice versa. Strikingly, the switch from DR to AL acutely increases mortality, whereas the switch from AL to DR causes only a weak and gradual increase in survival, suggesting the body has a memory of earlier nutrition. RNA sequencing in liver and brown and white adipose tissue (BAT and WAT, respectively) demonstrates a largely refractory transcriptional and metabolic response in fat tissue to DR after an AL diet, particularly in WAT, and a proinflammatory signature in aged preadipocytes, which is prevented by chronic DR feeding. Our results provide evidence for a ‘nutritional memory’ as a limiting factor for DR-induced longevity and metabolic remodelling of WAT in mammals.

First Authors:
Oliver Hahn

Correspondence Authors:
Michael J O Wakelam,Andreas Beyer,Sebastian Grönke,Linda Partridge

All Authors:
Oliver Hahn,Lisa F Drews,An Nguyen,Takashi Tatsuta,Lisonia Gkioni,Oliver Hendrich,Qifeng Zhang,Thomas Langer,Scott Pletcher,Michael J O Wakelam,Andreas Beyer,Sebastian Grönke,Linda Partridge

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Nature Reviews Endocrinology期刊

Dietary restriction in old age does not extend life

Anna Kriebs,2019-11-13

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Nature子刊:吃得越饱,死得越早

中国生物技术网,2020-04-10

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Nature子刊:吃得越饱,死得越早

2019-12-24

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Nature Metabolism期刊

The diet and the damage done

Stephen J. Simpson, David G. Le Couteur ,2019-10-21

点评:Nature Metabolism同期配发的新闻评论文章。

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Nature子刊:吃得越饱,死得越早

2019-11-04

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