动物实验证明,肥胖妈妈妊娠后更易造成认知及行为障碍
创作:尹小甜 审核:Epi汪 02月19日
  • 将四周龄雌性CD-1小鼠分为高脂饲料(HFD)组和常规饮食(RCD)组,而后让其怀孕妊娠;
  • HFD组小鼠体重显著增加,葡萄糖耐量受损;
  • 产前,两组小鼠在焦虑样行为方面未显示出统计学差异;
  • 而在产后断奶前,HFD组小鼠呈现快感缺乏,而断奶后,HFD组小鼠呈现更高的焦虑样行为;
  • 高脂饮食引起的肥胖或可导致女性在妊娠期前后认知功能及行为障碍,其中的生物学机制有待进一步研究。
主编推荐语
Epi汪
女性肥胖除了可能导致妊娠期糖尿病、巨大儿等与肥胖密切相关的母婴健康损害,也可能导致女性产后认知和行为障碍,如焦虑等。近年来,产后抑郁问题受到公众的关注,而女性肥胖问题是否在其中也扮演作用,值得进一步探索。
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Effects of high fat diet-induced obesity and pregnancy on prepartum and postpartum maternal mouse behavior

高脂饮食诱导的肥胖和妊娠对产前和产后母鼠行为的影响

10.1016/j.psyneuen.2021.105147

01-19, Article

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Obesity before and during pregnancy negatively affects the mental and physical health of the mother. A diet high in fat also increases the risk for anxiety, depression and cognitive dysfunction. We examined the effects of high fat diet (HFD) -induced obesity and pregnancy on maternal behavior, cognitive function and anxiety- and depression-like behaviors in mice. Four-week-old female CD-1 mice were placed on a HFD or regular chow diet (RCD) for 5 weeks. Mice were maintained on either diet as non-pregnant HFD and RCD groups, or allowed to breed, and then fed these diets throughout gestation, lactation and after weaning, as pregnant HFD and RCD groups. Mice on HFD but not on RCD for 5 weeks pre-pregnancy significantly gained weight and had impaired glucose clearance. Maternal behavior was assessed by nest building prepartum and pup-retrieval postpartum. Anxiety-like behavior was evaluated both prepartum and postpartum by elevated plus maze and cognitive function was assessed by the novel object recognition test postpartum. Anhedonia, a measure of impaired reward function, is an endophenotype of depression and was assessed by sucrose preference test pre- and post-weaning in dams. Mice on HFD in pregnancy exhibited both impaired maternal behavior and cognitive function in the postpartum period. We did not detect measurable differences between the HFD and RCD groups in anxiety-like behavior in the prepartum period. In contrast, HFD was also associated with anhedonia in pregnant mice pre- weaning, and anxiety-like behavior post-weaning. Thus, HFD has a negative effect on maternal behavior in the outbred CD-1 mouse, which provides a model to study associated outcomes and related mechanisms.

First Authors:
Showall Moazzam

Correspondence Authors:
Peter A Cattini

All Authors:
Showall Moazzam,Jessica S Jarmasz,Yan Jin,Tabrez J Siddiqui,Peter A Cattini

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