高脂饮食及槲皮素通过调节肠道菌群影响小鼠的NAFLD发展
创作:吴芹 审核:szx 2019年02月21日
  • 根据对高脂饮食(HFD)和槲皮素的应答选择供体小鼠,将肠道菌群移植给无菌小鼠;
  • 移植了HDF无应答或槲皮素高应答供体小鼠的肠道菌群的受体小鼠,在HFD诱导的非酒精性脂肪性肝病(NAFLD)中表现出保护性表型,该保护作用与肠-肝轴的变化相关;
  • 移植了HFD高应答供体小鼠的肠道菌群的受体小鼠,表现出NAFLD的易感性;
  • 在预防肥胖相关NAFLD发展中,Akk菌发挥主要作用。
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szx
Molecular Nutrition and Food Research上发表的一项最新研究,通过给无菌小鼠进行粪菌移植,发现高脂饮食或槲皮素可通过调节肠道菌群,影响肥胖相关NAFLD的易感性。
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Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice

肠道菌群移植、槲皮素和高脂饮食之间的功能互作决定了无菌小鼠非酒精性脂肪肝的发生

10.1002/mnfr.201800930

2019-01-24, Article

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SCOPE: Modulation of intestinal microbiota has emerged as a new therapeutic approach for non-alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development.
METHODS AND RESULTS: Gut microbiota donor mice are selected according to their response to high-fat diet (HFD) and quercetin in terms of obesity and NAFLD-related biomarkers. Germ-free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut-liver axis alteration blockage in these receivers. Gut microbiota from the HFD-responder donor predisposed transplanted germ-free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity-associated NAFLD development.
CONCLUSIONS: The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity-related NAFLD.

First Authors:
David Porras

Correspondence Authors:
Sonia Sánchez-Campos

All Authors:
David Porras,Esther Nistal,Susana Martínez-Flórez,José Luis Olcoz,Ramiro Jover,Francisco Jorquera,Javier González-Gallego,María Victoria García-Mediavilla,Sonia Sánchez-Campos

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