中科院:褪黑素调控小鼠肠道菌群,改善代谢紊乱
创作:卓求 审核:szx 2018年10月01日
  • 小鼠随机分为三个组:对照组、高脂饮食组、高脂饮食+褪黑素(MEL)组,评估MEL对高脂饮食小鼠脂代谢的影响及肠道菌群的变化;
  • MEL可显著缓解高脂饮食引起的脂质堆积、血清甘油三酯增加,并改善脂肪组织及肝脏中的脂代谢相关基因表达;
  • MEL可恢复高脂饮食引起的肠道菌群失调及菌群功能变化(包括氨基酸、能量、辅因子与维生素、碳水化合物的代谢);
  • MEL可提高粪便乙酸的含量,口服乙酸钠可改善脂代谢并抑制肝脏P38信号通路的转导。
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szx
来自中国科学院亚热带农业生态研究所在Journal of Pineal Research上发表的一项最新研究,表明褪黑素可改善高脂饮食诱导的小鼠代谢紊乱,其机制可能与调控肠道菌群有关。
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Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet‐fed mice

褪黑素调控肠道菌群改善高脂饮食诱导的小鼠脂代谢紊乱

10.1111/jpi.12524

2018-09-19, Article

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Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation, and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high fat‐induced lipid accumulation in antibiotic‐treated mice; however, microbiota transplantation from melatonin‐treated mice alleviated high fat diet‐induced lipid metabolic disorders. Notably, short‐chain fatty acids were decreased in high fat diet‐fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high fat diet‐induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high fat diet‐fed mice and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes‐mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

First Authors:
Jie Yin,Yuying Li

Correspondence Authors:
Xin Wu,Tiejun Li,Wenkai Ren

All Authors:
Jie Yin,Yuying Li,Hui Han,Shuai Chen,Jing Gao,Gang Liu,Xin Wu,Jinping Deng,Qifang Yu,Xingguo Huang,Rejun Fang,Tiejun Li,Russel J Reiter,Dong Zhang,Congrui Zhu,Guoqiang Zhu,Wenkai Ren,Yulong Yin

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