生命早期口服抗生素或不影响肺功能
创作:nana 审核:nana 2019年12月06日
  • 纳入620名有家族过敏史的婴儿,收集从出生到2岁使用抗生素的信息,包括抗生素类型及其适应症;
  • 在12岁和18岁时测定肺活量,并进行GST(谷胱甘肽s-转移酶)-P、GST-M和GST-T多态性基因分型;
  • 增加抗生素使用天数和更早使用抗生素,都与一秒内最大呼气量(FEV1)肺活量(FVC)减少无关;
  • 给GST缺失基因型儿童、生命早期出现气喘症状的儿童使用抗生素,不损害肺功能也不增加哮喘风险;
  • 使用特定类型的抗生素也与肺功能损害无关。
主编推荐语
nana
生命早期使用抗生素对肺功能是否具有损害作用,某些特定类型的抗生素其潜在的有害作用是否更大,谷胱甘肽s -转移酶(GST)遗传突变的儿童生命早期使用抗生素是否面临更大的健康风险。Chest发表的研究,招募620名有家族过敏史的儿童,收集出生到2岁前使用抗生素的信息,针对以上问题进行了研究,发现,在生命早期口服抗生素与有过敏性疾病家族史的儿童肺功能下降无关。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Chest [IF:9.41]

Early life exposure to oral antibiotics and lung function into early adulthood

早期口服抗生素和成年早期肺功能

10.1016/j.chest.2019.10.004

2019-10-24, Article

Abstract & Authors:展开

Abstract:收起
Background: Although there is ongoing debate regarding the impact of early postnatal exposure to antibiotics on the development of asthma, the possibility that antibiotic exposure may impair lung function has not previously been examined. Furthermore, it is unclear if specific types of antibiotics may have a greater effect, or if children with genetic mutations in the oxidative stress response glutathione S-transferase (GST) superfamily may be at greater risk.
Methods: Parent-reported data of childhood antibiotic use from birth to 2 years, including type and indication, were collected from a birth cohort of 620 infants with a family history of allergy. Spirometry was performed at age 12 and 18 years, and results are presented as z scores. Participants were genotyped for GST-P, GST-M, and GST-T polymorphisms. Linear regression models were used to investigate the associations while adjusting for confounding factors.
Results: Neither increasing days of exposure nor earlier exposure to antibiotics was associated with reduced FEV1 (at 18 years, per doubling of days of exposure = –0.03 z score units; 95% CI, –0.11 to 0.04) or FVC (< 0.01; 95% CI, –0.08 to 0.07). There was no evidence that GST-risk polymorphisms (M1, P1, and T1) increased susceptibility, and specific types of antibiotics also did not increase risk of lung function deficits.
Conclusions: Increasing exposure to oral antibiotics in early postnatal life was not associated with reduced lung function in children with a family history of allergic diseases. Although unwarranted use of antibiotics in children should be minimized, concerns regarding long-term lung health should not be a driving influence for this rationalization of use.

First Authors:
Karoliny dos Santos

Correspondence Authors:
Shyamali C Dharmage

All Authors:
Karoliny dos Santos,Caroline J Lodge,Michael J Abramson,Bircan Erbas,Catherine M Bennett,Jennie Hui,Shyamali C Dharmage,Adrian J Lowe

评论