Nature子刊:一种菌群代谢物通过肠-肺轴缓解气道炎症
创作:mildbreeze 审核:mildbreeze 02月01日
  • MD4小鼠是一种抗体库有限的动物模型,能抵抗过敏性气道疾病,同笼试验表明这与其菌群的保护作用有关;
  • MD4小鼠的肠道菌群组成和功能发生改变,有很强的代谢L-酪氨酸的能力,使得生成的对甲酚硫酸酯(PCS)增加;
  • 补充L-酪氨酸或PCS能减轻哮喘模型小鼠的气道炎症反应;
  • 机制上,PCS能通过解耦连EGFR和TLR4信号,选择性地抑制肺上皮细胞生成趋化因子CCL20,从而减少树突细胞活化,发挥抗气道炎症的作用。
主编推荐语
mildbreeze
肠道菌群可以通过肠-肺轴途径,影响个体对哮喘等过敏性气道疾病的易感性。Nature Immunology发表的一项最新研究,使用一种抗体库受限的小鼠模型,鉴定出一种由宿主抗体与微生物互作塑造的肠道菌群变化,使得L-酪氨酸的菌群代谢产物——对甲酚硫酸酯在小鼠体内富集,从而保护小鼠抵抗哮喘等过敏性气道炎症。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Nature Immunology [IF:20.479]

Microbial metabolism of L-tyrosine protects against allergic airway inflammation

L-酪氨酸的微生物代谢防止气道变应性炎症

10.1038/s41590-020-00856-3

01-25, Article

Abstract & Authors:展开

Abstract:收起
The constituents of the gut microbiome are determined by the local habitat, which itself is shaped by immunological pressures, such as mucosal IgA. Using a mouse model of restricted antibody repertoire, we identified a role for antibody–microbe interactions in shaping a community of bacteria with an enhanced capacity to metabolize L-tyrosine. This model led to increased concentrations of p-cresol sulfate (PCS), which protected the host against allergic airway inflammation. PCS selectively reduced CCL20 production by airway epithelial cells due to an uncoupling of epidermal growth factor receptor (EGFR) and Toll-like receptor 4 (TLR4) signaling. Together, these data reveal a gut microbe–derived metabolite pathway that acts distally on the airway epithelium to reduce allergic airway responses, such as those underpinning asthma.

First Authors:
Tomasz P Wypych

Correspondence Authors:
Tomasz P Wypych,Benjamin Marsland

All Authors:
Tomasz P Wypych,Céline Pattaroni,Olaf Perdijk,Carmen Yap,Aurélien Trompette,Dovile Anderson,Darren J Creek,Nicola L Harris,Benjamin Marsland

评论