益生菌发酵的糖化乳蛋白缓解小鼠的轻度应激
创作:王文东 审核:szx 2020年07月30日
  • 小鼠随机分为5组:对照、不可预见的慢性轻度应激(UCMS)7周+对照饮食、UCMS+氟西汀、UCMS+糖化乳酪蛋白(Gc)、UCMS+鼠李糖乳杆菌4B15发酵的Gc(FGc)干预10周;
  • FGc可显著减少UCMS诱导的焦虑样行为,并改善应激引起的血清皮质酮升高和5-羟色胺下降;
  • UCMS诱导神经内分泌功能、神经元发育、炎症和肠-血-脑屏障功能相关的基因和蛋白表达异常,FGc处理可恢复;
  • FGc可恢复UCMS诱导的肠道菌群改变,与脑功能及行为特征相关。
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szx
Gut Microbes上发表的一项最新研究,在轻度应激后的小鼠中,发现鼠李糖乳杆菌4B15发酵的糖化乳酪蛋白可恢复应激诱导的肠道菌群失调,调节神经、炎症、肠道屏障、血脑屏障相关基因及蛋白的表达,减少焦虑样行为并改善神经内分泌功能。
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Gut Microbes [IF:7.74]

Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition

鼠李糖乳杆菌发酵的糖化乳蛋白改善轻度应激条件下小鼠的认知健康

10.1080/19490976.2020.1756690

2020-06-23, Article

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This study aimed to investigate the effects of glycated milk casein (Gc) fermented with Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and behavioral properties in mice under chronic stress. Mice were administered Gc or FGc for 10 weeks and then exposed to unpredictable chronic mild stress (UCMS) for 7 weeks. FGc administration restored alterations of gut microbiota induced by UCMS. Moreover, FGc significantly reduced the stress-induced increase in serum corticosterone and decrease in serotonin levels. Anxiety-like behaviors induced by UCMS were also significantly decreased in the FGc group. UCMS-induced dysregulation of gene and protein expression related to neuroendocrine function, neuronal development, and inflammation, and gut-blood-brain barrier function was controlled by FGc pre-treatment. These results strongly suggest the protective effects of FGc targeting of intestinal microbiota for abnormal brain activity, which is consistent with the view that FGc plays an important role in regulating stress-related gut-brain axis disorders.

First Authors:
Nam Su Oh,Jae Yeon Joung

Correspondence Authors:
Younghoon Kim,Hyung Wook Kim,Sae Hun Kim

All Authors:
Nam Su Oh,Jae Yeon Joung,Ji Young Lee,Jae Gwang Song,Sangnam Oh,Younghoon Kim,Hyung Wook Kim,Sae Hun Kim

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