Nature:早发1型糖尿病的早期菌群特征
  • 纳入783名有1型糖尿病(T1D)遗传风险的白人儿童,分析粪便宏基因组的纵向变化,并进行巢式病例对照分析;
  • 对照儿童菌群中,与细菌发酵和短链脂肪酸生物合成相关的基因含量更高,但未鉴定出具有普遍性的与胰岛自身免疫或 T1D显著相关的菌群成员;
  • 婴儿肠道菌群发育呈现动态变化和个体差异,出生第一年内以双歧杆菌属(两歧/短/长双歧杆菌)或变形菌门为优势菌;
  • 含有利用人乳寡糖基因的长双歧杆菌菌株,特异存在于母乳喂养婴儿中。
主编推荐语
mildbreeze
1型糖尿病(T1D)是一种自身免疫疾病,与遗传和环境因素有关。TEDDY研究是一项美国和欧洲的多中心纵向队列研究,分析有T1D遗传风险的婴幼儿的肠道菌群等潜在T1D风险因素。Nature刚刚上线两项基于该队列的研究,本研究主要分析了与T1D相关的肠道菌群功能和组成特征,表明短链脂肪酸对T1D有潜在预防作用。该研究也分析了婴幼儿期肠道菌群发育的规律,不妨与另一项研究(查看文章)搭配阅读。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Nature [IF:42.778]

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

TEDDY研究中早发1型糖尿病中的人体肠道菌群

10.1038/s41586-018-0620-2

2018-10-24, Article

Abstract & Authors:展开

Abstract:收起
Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors, including complex genetic elements, patient exposures and the gut microbiome. Viral infections and broader gut dysbioses have been identified as potential causes or contributing factors; however, human studies have not yet identified microbial compositional or functional triggers that are predictive of islet autoimmunity or T1D. Here we analyse 10,913 metagenomes in stool samples from 783 mostly white, non-Hispanic children. The samples were collected monthly from three months of age until the clinical end point (islet autoimmunity or T1D) in the The Environmental Determinants of Diabetes in the Young (TEDDY) study, to characterize the natural history of the early gut microbiome in connection to islet autoimmunity, T1D diagnosis, and other common early life events such as antibiotic treatments and probiotics. The microbiomes of control children contained more genes that were related to fermentation and the biosynthesis of short-chain fatty acids, but these were not consistently associated with particular taxa across geographically diverse clinical centres, suggesting that microbial factors associated with T1D are taxonomically diffuse but functionally more coherent. When we investigated the broader establishment and development of the infant microbiome, both taxonomic and functional profiles were dynamic and highly individualized, and dominated in the first year of life by one of three largely exclusive Bifidobacterium species (B. bifidum, B. breve or B. longum) or by the phylum Proteobacteria. In particular, the strain-specific carriage of genes for the utilization of human milk oligosaccharide within a subset of B. longum was present specifically in breast-fed infants. These analyses of TEDDY gut metagenomes provide, to our knowledge, the largest and most detailed longitudinal functional profile of the developing gut microbiome in relation to islet autoimmunity, T1D and other early childhood events. Together with existing evidence from human cohorts and a T1D mouse model, these data support the protective effects of short-chain fatty acids in early-onset human T1D.

First Authors:
Tommi Vatanen

Correspondence Authors:
Curtis Huttenhower,Ramnik J Xavier

All Authors:
Tommi Vatanen,Eric A Franzosa,Randall Schwager,Surya Tripathi,Timothy D Arthur,Kendra Vehik,Åke Lernmark,William A Hagopian,Marian J Rewers,Jin-Xiong She,Jorma Toppari,Anette-G Ziegler,Beena Akolkar,Jeffrey P Krischer,Christopher J Stewart,Nadim J Ajami,Joseph F Petrosino,Dirk Gevers,Harri Lähdesmäki,Hera Vlamakis,Curtis Huttenhower,Ramnik J Xavier

图片
菌探Momics微信公众号

Nature | TEDDY研究中早发1型糖尿病的肠道微生物组

菌探Momics,2018-11-20

点评:菌探Momics 全文解读

评论