精神益生制剂能否改善抑郁?(综述)
创作:大力 审核:mildbreeze 2019年07月25日
  • 纳入32项评估精神益生制剂(包括益生菌、益生元和合生制剂)对成人抑郁症状的效果的随机临床试验;
  • 仅7项研究显示精神益生制剂有显著的抗抑郁作用;
  • 部分益生菌株或有助于改善抑郁,如瑞士乳杆菌R0052+长双歧杆菌R0175、凝结芽孢杆菌MTCC5856、丁酸梭菌CBM588等,但不同研究结果不一致;
  • 对益生元或合生制剂对抑郁症的影响研究较少,尚无定论;
  • 研究的总体偏倚风险不明,许多实验设计未考虑性别、体重、饮食和身体活动等主要混杂因素。
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mildbreeze
《Clinical Nutrition》近期发表一项系统综述,纳入了32项临床试验研究,对包括益生菌、益生元和合生制剂的精神益生制剂改善抑郁症状的作用,进行了综合分析,表明某些益生菌株或组合可能有助于改善抑郁,但目前的证据还不足以下结论,仍需更多精心设计的高质量临床试验。
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Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

精神益生制剂能让肠道“情绪”化吗?关于益生菌、益生元和合生制剂对健康和临床受试者的抗抑郁作用的随机对照试验的一项最新系统综述

10.1016/j.clnu.2019.06.004

2019-06-11, Article

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Background & aims: Depression is a major debilitating health problem with high global prevalence. Gut microbiota dysbiosis might be implicated in pathophysiology of depression. Hence, probiotics, prebiotics and synbiotics (psychobiotics) have been administered in clinical trials in attempt to relieve depressive symptoms. This update systematic review aimed to evaluate the current body of research concerning the effects of psychobiotics on depression.
Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed in this review. Search was performed in MEDLINE, ProQuest, EMBASE, PsycNET, and Scopus databases for randomized clinical trials which assessed the effects of psychobiotics on depressive symptoms among adults, and were published in English language, since inception until September 2018.
Results: Out of 3374 records screened, 32 articles met the study criteria; only seven studies reported significant anti-depressant effects of psychobiotics. Some probiotic strains showed beneficial effects on depressive symptoms; the results were inconsistent, though. Few studies investigated the effects of prebiotics or synbiotics on depression, and did not come up with much promising results The overall risk of bias was judged to be unclear across the included studies, and major confounding factors were not considered in their design.
Conclusion: Since probiotics may affect depression in strain-specific manner, the current evidence is not sufficient to either support or decline anti-depressant effects of probiotics; results of studies on prebiotics and synbiotics are not conclusive, either. More well-designed studies with emphasis on specific probiotic strains, inter-individual gut microbiota variations, and depression subtypes are warranted.

First Authors:
Elnaz Vaghef Mehrabany

Correspondence Authors:
Mehrangiz Ebrahimi Mameghani

All Authors:
Elnaz Vaghef Mehrabany,Vahid Maleki,Maryam Behrooz,Fatemeh Ranjbar,Mehrangiz Ebrahimi Mameghani

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