贾伟+李后开:肠道菌群-胆汁酸-脑轴可能参与阿尔茨海默病和肝性脑病
  • 胆固醇稳态失衡及其在脑内过度积累,参与淀粉样蛋白(Aβ)生成途径,促进阿尔茨海默症(AD)和肝性脑病(HE);
  • 肝脏消耗胆固醇生成胆汁酸(BA),肠道菌群可转化和代谢BA,从而影响血液和大脑BA谱,BA组成及其脑内受体活化的变化参与疾病进展;
  • AD和HE患者的肠道菌群改变,菌群失调还可通过增加肠道通透性、诱导神经炎症、促进Aβ沉积等机制,诱发疾病;
  • 靶向肠道菌群‐BA‐脑轴,调整菌群的组成和功能或是抗AD/HE的新策略。
主编推荐语
mildbreeze
Medicinal Research Reviews近期发表了由夏威夷大学癌症中心贾伟与上海中医药大学李后开等人主笔的专家观点文章,结合最新的研究发现,阐述了阿尔茨海默病(AD)和肝性脑病(HE)中的肠道菌群失调、胆汁酸和胆固醇代谢紊乱的作用,提出菌群相关的胆汁酸稳态失衡可能在机制上参与了AD和HE的疾病进展,因此靶向肠道菌群-胆汁酸-脑轴或是防治AD和HE的新思路。
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Expert insights: The potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy

专家观点:肠道菌群-胆汁酸-脑轴在阿尔茨海默病和肝性脑病的发展和进展中的潜在作用

10.1002/med.21653

2019-12-05, Article

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Recent epidemiological and molecular studies have linked the disruption of cholesterol homeostasis to increased risk for developing Alzheimer's disease (AD). Emerging evidence also suggests that brain cholesterol accumulation contributes to the progression of hepatic encephalopathy (HE) via bile acid (BA)‐mediated effects on the farnesoid X receptor. In this perspective paper, we reviewed several recently published studies that suggested a role for the gut microbiota transformation of BAs as a factor in AD and HE development/progression. We hypothesize that in addition to cholesterol elimination pathways, alteration of the gut microbiota and subsequent changes in both the serum and brain BA profiles are mechanistically involved in the development of both AD and HE, and thus, are a potential target for the prevention and treatment of the two diseases. Our understanding of the microbiome‐BAs‐brain axis in central nervous system disease is still evolving, and critical questions regarding the emerging links among central, peripheral, and intestinal metabolic failures contributing to brain health and disease during aging have yet to be addressed.

First Authors:
Wei Jia

Correspondence Authors:
Wei Jia,Houkai Li

All Authors:
Wei Jia,Cynthia Rajani,Rima Kaddurah‐Daouk,Houkai Li

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