海外华人团队:幽门螺杆菌感染者宜少吃辣椒
创作:this little piggy 审核:Lexi 05月04日
  • 幽门螺杆菌(H. pylori)感染联合辣椒素灌胃,共同诱导C57-Balb/c小鼠从胃炎到胃癌的进行性转变;
  • 处理后32周时诱发胃炎,52周时诱发胃癌(发生率50%);
  • H. pylori和辣椒素加重胃组织损伤,降低抑癌基因表达,显著增加促炎细胞因子IL-6水平,降低IFN-γ水平;
  • 2-二氟甲基鸟氨酸(DFMO)治疗可调节IL-6和IFN-γ表达,减少炎症,促进无病停滞的恢复,预防胃癌发生;
  • 减少辣椒素摄入、清除H. pylori、DFMO治疗等措施可降低胃癌发病率。
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Lexi
环境、饮食和生活方式的改变,包括幽门螺杆菌(H. pylori)感染和食用辣椒(即辣椒素),会导致胃癌风险的变化。在辣椒素暴露的早期,H. pylori感染可促进胃粘膜损伤。来自美国明尼苏达大学的Zigang Dong研究团队在Cancers发表最新研究,探索了H. pylori感染和辣椒素导致胃炎症和胃癌发生的机制。该研究发现H. pylori感染和辣椒素摄入通过调控炎症细胞因子水平和抑癌基因表达,诱导小鼠胃炎从而诱发胃癌。使用抗炎剂2-二氟甲基鸟氨酸(DFMO)治疗减少炎症可预防胃癌发生。
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Cancers [IF:6.126]

Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

幽门螺杆菌联合辣椒素和2-二氟甲基鸟氨酸治疗分别对胃癌的诱导和预防作用

10.3390/cancers12040816

03-28, Article

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Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including Helicobacter pylori (H. pylori) infection and consumption of hot peppers (i.e., capsaicin). H. pylori infection promotes gastric mucosal injury in the early phase of capsaicin exposure. This relationship suggests a need to investigate the mechanism of how both H. pylori infection and capsaicin contribute to gastric inflammation and lead to gastric cancer. C57-Balb/c mice were infected with the H. pylori (SS1) strain and then fed capsaicin (0.05% or 0.2 g/kg/day) or not. Consequently, tumor size and phenotype were analyzed to determine the molecular mechanism driving the shift from gastritis to stomach cancer. Moreover, we used 2-difluoromethylornithine (DFMO) in mice to prevent gastric tumorigenesis by reducing inflammation and promoting recovery of disease-free stasis. This study provides evidence showing that a combination of H. pylori infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, H. pylori clearance, and DFMO treatment may lessen gastric cancer incidence.

First Authors:
Faisal Aziz

Correspondence Authors:
Zigang Dong

All Authors:
Faisal Aziz,Mingxia Xin,Yunfeng Gao,Abhijit Chakroborty,Imran Khan,Josh Monts,Kjersten Monson,Ann M Bode,Zigang Dong

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