鸡蛋摄入或与血脂,心血管疾病及死亡率无关
  • 纳入三个前瞻性队列研究(PURE,ONTARGET,TRANSCEND),约177 000人,横跨6个大洲,50个国家;
  • PURE研究随访9.5年,ONTARGET/TRANSCEND随访约5年,共记录12 701例死亡,13 658例心血管疾病(CVD)事件;
  • PURE研究显示,鸡蛋摄入量与血脂,综合结局(死亡+CVD),总死亡率,以及主要CVD事件并无统计学相关性(每周摄入≥7个鸡蛋与<1个鸡蛋相比);
  • 在ONTARGET/TRANSCEND这两个对列研究中,也发现了相似结果。
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American Journal of Clinical Nutrition近期发表的一项前瞻性研究,纳入来自50个国家,约177 000名受试者,探究鸡蛋摄入与血脂,心血管疾病及死亡率的关系。该研究发现,较高的鸡蛋摄入(每周≥7个鸡蛋)与较低摄入(每周<1个鸡蛋)相比,其血脂,心血管疾病风险,及死亡率并无明显差别。本研究得出的结论与去年发表在JAMA上的一项研究相反(查看文章)。但需注意的是,这两项研究基于的人群不同,不同的饮食背景或许会造成该差异。
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延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries

鸡蛋摄入与来自50个国家,约177000名受试者血脂,心血管疾病,和死亡率的关系

10.1093/ajcn/nqz348

01-21, Article

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Background Eggs are a rich source of essential nutrients, but they are also a source of dietary cholesterol. Therefore, some guidelines recommend limiting egg consumption. However, there is contradictory evidence on the impact of eggs on diseases, largely based on studies conducted in high-income countries. Objectives Our aim was to assess the association of egg consumption with blood lipids, cardiovascular disease (CVD), and mortality in large global studies involving populations from low-, middle-, and high-income countries. Methods We studied 146,011 individuals from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Egg consumption was recorded using country-specific validated FFQs. We also studied 31,544 patients with vascular disease in 2 multinational prospective studies: ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global End Point Trial) and TRANSCEND (Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects with Cardiovascular Disease). We calculated HRs using multivariable Cox frailty models with random intercepts to account for clustering by study center separately within each study. Results In the PURE study, we recorded 14,700 composite events (8932 deaths and 8477 CVD events). In the PURE study, after excluding those with history of CVD, higher intake of egg (≥7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.74), total mortality (HR: 1.04; 95% CI: 0.94, 1.15; P-trend = 0.38), or major CVD (HR: 0.92; 95% CI: 0.83, 1.01; P-trend = 0.20). Similar results were observed in ONTARGET/TRANSCEND studies for composite outcome (HR 0.97; 95% CI: 0.76, 1.25; P-trend = 0.09), total mortality (HR: 0.88; 95% CI: 0.62, 1.24; P-trend = 0.55), and major CVD (HR: 0.97; 95% CI: 0.73, 1.29; P-trend = 0.12). Conclusions In 3 large international prospective studies including ∼177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, we did not find significant associations between egg intake and blood lipids, mortality, or major CVD events.

First Authors:
Mahshid Dehghan

Correspondence Authors:
Mahshid Dehghan

All Authors:
Mahshid Dehghan,Andrew Mente,Sumathy Rangarajan,Viswanathan Mohan,Scott Lear,Sumathi Swaminathan,Andreas Wielgosz,Pamela Seron,Alvaro Avezum,Patricio Lopez-Jaramillo,Ginette Turbide,Jephat Chifamba,Khalid F Alhabib,Noushin Mohammadifard,Andrzej Szuba,Rasha Khatib,Yuksel Altuntas,Xiaoyun Liu,Romaina Iqbal,Annika Rosengren,Rita Yusuf,Marius Smuts,AfzalHussein Yusufali,Ning Li,Rafael Diaz,Khalid Yusoff,Manmeet Kaur,Biju Soman,Noorhassim Ismail,Rajeev Gupta,Antonio Dans,Patrick Sheridan,Koon Teo,Sonia S Anand,Salim Yusuf

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