蛋白摄入或增加晚期糖基化终末产物及其受体的浓度
创作:szx 审核:szx 2020年12月27日
  • 纳入2439名老年受试者,通过饮食问卷评估过去一年的蛋白摄入情况,并检测血清中的主要AGE羧甲基赖氨酸(CML)及可溶性AGE受体(sRAGE)的浓度;
  • 膳食蛋白摄入量越高,血清中的CML及sRAGE浓度越高;
  • 每日膳食总蛋白摄入每增加0.1g/kg,血清中的CML及sRAGE浓度分别增加13.3 ± 3.0 ng/ml及22.1 ± 6.0 pg/ml;
  • 血清中的高CML及sRAGE浓度与动物蛋白及植物蛋白的高摄入均显著相关。
主编推荐语
szx
晚期糖基化终末产物(AGE)对健康有不利影响,可在衰老过程中促进多系统功能衰退。富含蛋白的饮食可能增加循环中的AGE浓度。American Journal of Clinical Nutrition上发表的一项最新研究,对近2500名老年人的膳食蛋白摄入情况及血清AGE/AGE受体浓度进行分析后发现,膳食蛋白摄入量越高(无论是动物蛋白还是植物蛋白),血清中的主要AGE及AGE受体的浓度越高。
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Dietary protein intake and circulating advanced glycation end product/receptor for advanced glycation end product concentrations in the Health, Aging, and Body Composition Study

膳食蛋白摄入与循环晚期糖基化终末产物及其受体的浓度

10.1093/ajcn/nqaa241

2020-09-21, Article

Abstract & Authors:展开

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Background: Advanced glycation end products (AGEs) promote adverse health effects and may contribute to the multi-system functional decline observed in aging. Diet is a major source of AGEs, and foods high in protein may increase circulating AGE concentrations. However, epidemiological evidence that high-protein diets increase AGEs is lacking.
Objectives: We examined whether dietary protein intake was associated with serum concentrations of the major AGE carboxymethyl-lysine (CML) and the soluble receptor for AGEs (sRAGE) in 2439 participants from the Health, Aging, and Body Composition study (mean age, 73.6 ± 2.9 y; 52% female; 37% black).
Methods: CML and sRAGE were measured by ELISA, and the CML/sRAGE ratio was calculated. Protein intake was estimated using an interviewer-administered FFQ and categorized based on current recommendations for older adults: <0.8 g/kg/d (n = 1077), 0.8 to <1.2 g/kg/d (n = 922), and ≥1.2 g/kg/d (n = 440). Associations between protein intake and AGE-RAGE biomarkers were examined using linear regression models adjusted for demographics, height, lifestyle behaviors, prevalent disease, cognitive function, inflammation, and other dietary factors.
Results: CML concentrations were higher in individuals with higher total protein intake (adjusted least squares mean ± SE: <0.8 g/kg/d, 829 ± 17 ng/ml; 0.8 to <1.2 g/kg/d, 860 ± 15 ng/ml; ≥1.2 g/kg/d, 919 ± 23 ng/ml; P for trend = 0.001), as were sRAGE concentrations (<0.8 g/kg/d, 1412 ± 34 pg/ml; 0.8 to <1.2 g/kg/d, 1479 ± 31 pg/ml; ≥1.2 g/kg/d, 1574 ± 47 pg/ml; P for trend < 0.0001). Every 0.1 g/kg/d increment in total protein intake was associated with a 13.3 ± 3.0 ng/ml increment in CML and a 22.1 ± 6.0 pg/ml increment in sRAGE (P < 0.0001 for both). Higher CML and sRAGE concentrations were also associated with higher intakes of both animal and vegetable protein (all P values ≤ 0.01). There were no significant associations with the CML/sRAGE ratio.
Conclusions: Higher dietary protein intake was associated with higher CML and sRAGE concentrations in older adults; however, the CML/sRAGE ratio remained similar across groups.

First Authors:
Tina E Brinkley

Correspondence Authors:
Tina E Brinkley

All Authors:
Tina E Brinkley,Richard D Semba,Stephen B Kritchevsky,Denise K Houston,for the Health,Aging,Body Composition Study

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