国内团队:豆类及大豆食品摄入与2型糖尿病风险的关联
创作:徐笑 审核:szx 2020年02月05日
  • 纳入15项前瞻性队列研究(包含565810名受试者,其中32093名2型糖尿病患者)进行荟萃分析;
  • 总豆类、总大豆及豆奶的摄入与2型糖尿病风险无显著关联,豆腐、大豆蛋白和大豆异黄酮的摄入与2型糖尿病风险显著负相关;
  • 总豆类、总大豆和豆奶的摄入具有高度异质性,且受地理位置和研究质量影响,总豆类摄入的证据质量中等,总大豆及各种大豆食品摄入的证据质量较低;
  • 需要更多高质量、前瞻性的研究来验证哪些豆类食品或成分发挥有益作用。
主编推荐语
szx
来自浙江大学的冯凤琴团队与西湖大学的郑钜圣团队在American Journal of Clinical Nutrition上发表的一项荟萃分析结果,对15项涉及近60万人的前瞻性队列研究进行总结后发现,豆腐、大豆蛋白和大豆异黄酮的摄入与2型糖尿病风险显著负相关,但因证据质量较低,需更多高质量、前瞻性的研究来验证哪些豆类食品或成分发挥有益作用。
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Legume and soy intake and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies

豆类和大豆摄入与2型糖尿病风险:对前瞻性队列研究的系统性综述与荟萃分析

10.1093/ajcn/nqz338

2020-01-08, Communication

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Background: Previous findings on the associations of legume and soy intake with the risk of type 2 diabetes are conflicting.
Objective: We aimed to summarize the longitudinal associations between legume and soy intake and risk of type 2 diabetes.
Methods: We searched for relevant prospective cohort studies in PubMed, EMBASE, and Ovid up to August 2019. Study-specific, multivariable-adjusted RRs and 95% CIs were pooled by random-effects models.
Results: We identified 15 unique cohorts including 565,810 individuals and 32,093 incident cases. The summary RRs (95% CIs) of incident type 2 diabetes were 0.95 (0.79, 1.14; NS) for total legumes, 0.83 (0.68, 1.01; NS) for total soy, 0.89 (0.71, 1.11; NS) for soy milk, 0.92 (0.84, 0.99) for tofu, 0.84 (0.75, 0.95) for soy protein, and 0.88 (0.81, 0.96) for soy isoflavones, respectively. High heterogeneity was found for total legumes (I2 = 84.8%), total soy (I2 = 90.8%), and soy milk (I2 = 91.7%). Potential sources of heterogeneity were not evident for total legumes or soy milk, whereas for total soy, geographic location (Asia, United States; P = 0.04) and study quality (high, moderate, or low; P = 0.02) significantly predicted heterogeneity. In dose–response analysis, significant linear inverse associations were observed for tofu, soy protein, and soy isoflavones (all P < 0.05). Overall quality of evidence was rated as moderate for total legumes and low for total soy and soy subtypes.
Conclusions: Dietary intakes of tofu, soy protein, and soy isoflavones, but not total legumes or total soy, are inversely associated with incident type 2 diabetes. Our findings support recommendations to increase intakes of certain soy products for the prevention of type 2 diabetes. However, the overall quality of evidence was low and more high-quality evidence from prospective studies is needed. This trial was registered as PROSPERO CRD42019126403

First Authors:
Jun Tang

Correspondence Authors:
Jusheng Zheng,Fengqin Feng

All Authors:
Jun Tang,Yi Wan,Minjie Zhao,Hao Zhong,Jusheng Zheng,Fengqin Feng

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