JAMA:草药/中草药应对更年期综合征,靠谱么?
  • 40-50%西方妇女用补充疗法应对更年期综合征;
  • 分析62项随机对照实验,6653人;
  • 植物雌激素可减潮热和阴道干涩,通过饮食和大豆异黄酮补充也有改善,但都对盗汗无效;
  • 几种草药,但不是中草药,降低血管舒缩症状频率;
  • 研究质量差强人意,74%有3个或以上高风险偏见。
#中医药与菌群研究#
主编推荐语
蓝灿辉 | 热心肠先生
虽然不是直接的肠道菌群研究,但也分享给大家。更年期相关肠道菌群和更年期症状的关联研究,值得试一试。
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延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
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JAMA [IF:45.54]

Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis

植物性疗法的使用和更年期综合征:一个系统性综述和元分析

10.1001/jama.2016.8012

2016-06-22, Review

Abstract & Authors:展开

Abstract:收起
IMPORTANCE: Between 40% and 50% of women in Western countries use complementary therapies to manage menopausal symptoms.
OBJECTIVE: To determine the association of plant-based therapies with menopausal symptoms, including hot flashes, night sweats, and vaginal dryness.
DATA SOURCES: The electronic databases Ovid MEDLINE, EMBASE, and Cochrane Central were systematically searched to identify eligible studies published before March 27, 2016. Reference lists of the included studies were searched for further identification of relevant studies.
STUDY SELECTION: Randomized clinical trials that assessed plant-based therapies and the presence of hot flashes, night sweats, and vaginal dryness.
DATA EXTRACTION: Data were extracted by 2 independent reviewers using a predesigned data collection form.
MAIN OUTCOMES AND MEASURES: Hot flashes, night sweats, and vaginal dryness.
RESULTS: In total, 62 studies were identified, including 6653 individual women. Use of phytoestrogens was associated with a decrease in the number of daily hot flashes (pooled mean difference of changes, -1.31 [95% CI, -2.02 to -0.61]) and vaginal dryness score (pooled mean difference of changes, -0.31 [95% CI, -0.52 to -0.10]) between the treatment groups but not in the number of night sweats (pooled mean difference of changes, -2.14 [95% CI, -5.57 to 1.29]). Individual phytoestrogen interventions such as dietary and supplemental soy isoflavones were associated with improvement in daily hot flashes (pooled mean difference of changes, -0.79 [-1.35 to -0.23]) and vaginal dryness score (pooled mean difference of changes, -0.26 [-0.48 to -0.04]). Several herbal remedies, but not Chinese medicinal herbs, were associated with an overall decrease in the frequency of vasomotor symptoms. There was substantial heterogeneity in quality across the available studies, and 46 (74%) of the included randomized clinical trials demonstrated a high risk of bias within 3 or more areas of study quality.
CONCLUSIONS AND RELEVANCE: This meta-analysis of clinical trials suggests that composite and specific phytoestrogen supplementations were associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats. However, because of general suboptimal quality and the heterogeneous nature of the current evidence, further rigorous studies are needed to determine the association of plant-based and natural therapies with menopausal health.

First Authors:
Oscar H Franco

Correspondence Authors:
Taulant Muka

All Authors:
Oscar H Franco,Rajiv Chowdhury,Jenna Troup,Trudy Voortman,Setor Kunutsor,Maryam Kavousi,Clare Oliver-Williams,Taulant Muka

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