植物雌激素摄入或可降低乳腺癌死亡率及复发率
创作:王文东 审核:szx 2020年07月20日
  • 纳入28项前瞻性及回顾性队列研究进行系统性综述,分析植物雌激素摄入与不同癌症的关联;
  • 选取其中11项研究,对乳腺癌与植物雌激素摄入的关联进行定量荟萃分析;
  • 7项研究(9个队列)的数据表明,较高的膳食异黄酮摄入量与总死亡率和乳腺癌复发率呈显著负相关;
  • 2项研究的数据表明,较高的血清/血浆肠内酯浓度(木酚素摄入的生物标志物)与绝经后女性的总死亡率及乳腺癌死亡率呈显著负相关;
  • 植物雌激素摄入与其它癌症的关联的证据较少。
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szx
Nutrition Reviews上发表的一项系统性综述与荟萃分析的结果:对11项前瞻性及回顾性队列研究进行总结后发现,异黄酮的摄入与总死亡率及乳腺癌复发率呈负相关,而木酚素的摄入与绝经后女性的总死亡率及乳腺癌死亡率呈负相关;纳入28项前瞻性及回顾性队列进行总结后发现,对植物雌激素摄入与乳腺癌之外的其它癌症的关联的研究较少。
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Dietary phytoestrogens and biomarkers of their intake in relation to cancer survival and recurrence: a comprehensive systematic review with meta-analysis

膳食植物雌激素及其摄入的生物标记物与癌症存活和复发的关联:一项综合系统性综述与荟萃分析

10.1093/nutrit/nuaa043

2020-07-06, Article

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Context: Recent studies have outlined the potential role of dietary factors in patients who have survived cancer.
Objective: The aim of this study was to summarize the evidence of the relation between dietary intake of phytoestrogens and their blood biomarkers and, overall, cancer-specific mortality and recurrence in patients with cancer.
Data Sources: A systematic search of PubMed, EMBASE, and Web of Science databases of studies published up to September 2019 was performed. Databases were searched for prospective and retrospective cohort studies reporting on dietary phytoestrogen intake and/or blood biomarkers and the outcomes investigated.
Data extraction: Data were extracted from each identified study using a standardized form.
Data analysis: Twenty-eight articles on breast, lung, prostate, and colorectal cancer, and glioma were included for systematic review. Given the availability of studies, a quantitative meta-analysis was performed solely for breast cancer outcomes. A significant inverse association among higher dietary isoflavone intake, higher serum/plasma enterolactone concentrations, and overall mortality and cancer recurrence was found. Among other cancer types, 2 studies reported that higher serum enterolactone and higher intake of lignans were associated with cancer-specific survival for colorectal cancer and glioma, respectively.
Conclusions: Dietary phytoestrogens may play a role in survival from breast cancer ; evidence regarding other cancers is too limited to draw any conclusions.

First Authors:
Agnieszka Micek

Correspondence Authors:
Justyna Godos

All Authors:
Agnieszka Micek,Justyna Godos,Tomasz Brzostek,Agnieszka Gniadek,Claudia Favari,Pedro Mena,Massimo Libra,Daniele Del Rio,Fabio Galvano,Giuseppe Grosso

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