新视角——微生态角度评估膳食乳化剂
创作:lzm 审核:周旸 03月31日
  • 利用肠道微生态体外模拟系统检验20种膳食乳化剂的影响,发现除了卵磷脂外,大部分乳化剂对菌群的结构和功能有负面影响;
  • 山梨醇酐单硬脂酸酯和硬脂酸甘油酯等会长效增加微生物密度,而琼脂、DATEM、HPMC和油酸甘油酯等不可逆地降低微生物密度;
  • 不同乳化剂对菌群多样性的影响有差异,硬脂酸甘油酯等通过增加脂多糖、鞭毛蛋白等分子的释放,有可能促进肠道炎症;
  • 聚山梨酯80等不可逆地改变微生态结构和功能,应优先评估其体内影响。
主编推荐语
周旸
膳食乳化剂对肠道炎症、代谢疾病的负面影响近年来得到关注。Microbiome近期发表一项研究,利用体外的肠道微生态模拟系统检测20种常用膳食乳化剂对于肠道菌群的影响,发现尽管不同乳化剂对于微生态的改变具有差异性,大部分乳化剂对肠道菌群的结构和功能具有负面影响,有必要从肠道微生态角度对这类添加剂的安全性进行重新评估。这一结果对于食品添加剂的筛选、安全性的评估提出了新见解,值得参考。
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Microbiome [IF:11.607]

Direct impact of commonly used dietary emulsifiers on human gut microbiota

常用膳食乳化剂对人体肠道菌群产生直接影响

10.1186/s40168-020-00996-6

03-22, Article

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Background: Epidemiologic evidence and animal studies implicate dietary emulsifiers in contributing to the increased prevalence of diseases associated with intestinal inflammation, including inflammatory bowel diseases and metabolic syndrome. Two synthetic emulsifiers in particular, carboxymethylcellulose and polysorbate 80, profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states. In contrast, the extent to which other food additives with emulsifying properties might impact intestinal microbiota composition and function is not yet known.
Methods: To help fill this knowledge gap, we examined here the extent to which a human microbiota, maintained ex vivo in the MiniBioReactor Array model, was impacted by 20 different commonly used dietary emulsifiers. Microbiota density, composition, gene expression, and pro-inflammatory potential (bioactive lipopolysaccharide and flagellin) were measured daily.
Results: In accordance with previous studies, both carboxymethylcellulose and polysorbate 80 induced a lasting seemingly detrimental impact on microbiota composition and function. While many of the other 18 additives tested had impacts of similar extent, some, such as lecithin, did not significantly impact microbiota in this model. Particularly stark detrimental impacts were observed in response to various carrageenans and gums, which altered microbiota density, composition, and expression of pro-inflammatory molecules.
Conclusions: These results indicate that numerous, but not all, commonly used emulsifiers can directly alter gut microbiota in a manner expected to promote intestinal inflammation. Moreover, these data suggest that clinical trials are needed to reduce the usage of the most detrimental compounds in favor of the use of emulsifying agents with no or low impact on the microbiota.

First Authors:
Sabrine Naimi

Correspondence Authors:
Benoit Chassaing

All Authors:
Sabrine Naimi,Emilie Viennois,Andrew T Gewirtz,Benoit Chassaing

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