国内团队:备孕夫妻应做好体重管理
创作:Epi汪 审核:Epi汪 2020年10月30日
  • 纳入国家免费孕前检查项目中230万对夫妻,探索孕前夫妻双方BMI和待孕时间(TTP)的关联;
  • 按照中国的划分标准,女性低体重、超重和肥胖,以及男性的低体重是影响夫妻生育力的危险因素;
  • 女性生育力最佳的BMI范围是20.61-23.06kg/m2,而男性最佳的BMI范围在22.69-27.74kg/m2;
  • 妻子肥胖,而丈夫低体重者,其生育力下降约30%;
  • 夫妻双方都肥胖者,生育力下降19%;
  • 备孕夫妻应该做好体重管理,避免营养不良或肥胖。
主编推荐语
Epi汪
来自国家卫健委科研所、协和医学院、重庆医科大学附属第一医院等单位的研究团队通过分析我国孕前优生健康检查数据库,发现孕前夫妻BMI与待孕时间(生育力)存在关联。本研究发表在《Fertility and Sterility》上,对孕前健康咨询和指导具有重要的指导意义。
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Couples' prepregnancy body mass index and time to pregnancy among those attempting to conceive their first pregnancy

首次备孕夫妻的孕前BMI与待孕时间的关联

10.1016/j.fertnstert.2020.05.041

2020-10-14, Article

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Objective: To explore the relationship between couples’ prepregnancy body mass index (BMI) and time to pregnancy (TTP) among those with no prior gravidity
Setting: Local maternal/child health care or family-planning service institutions
Patient: A total of 2,301,782 eligible couples participating in the National Free Preconception Check-up Projects from January 1,2015 to December 31, 2017.
Result: Underweight, overweight, or obese status in women and underweight status in men were associated with couples’ prolonged TTP. The optimal BMI levels were 20.61–23.06 kg/m2 and 22.69–27.74 kg/m2 for women and men, respectively. Compared with couples in whom both partners had a normal BMI, the pregnancy rates were reduced by 10% (fecundability odds ratio [FOR] 0.90; 95% confidence interval [CI], 0.88–0.92) and 19% (FOR 0.81; 95% CI, 0.78–0.84) for couples in whom both partners were underweight or obese, respectively. The combination of women with a normal BMI and overweight men had the greatest fertility (FOR 1.03; 95% CI, 1.02– 1.03), and the combination of obese women and underweight men had the lowest fertility (FOR 0.70; 95% CI, 0.65–0.76).
Conclusion: Abnormal prepregnancy BMIs in either women or men were associated with prolonged TTP among couples with no prior gravidity. Scientific management of couples’ prepregnancy BMI could improve their fertility

First Authors:
Yue Zhang,Junhui Zhang

Correspondence Authors:
Jun Zhao,Xu Ma

All Authors:
Yue Zhang,Junhui Zhang,Jun Zhao,Xiang Hong,Hongguang Zhang,Qiaoyun Dai,Yuanyuan Wang,Xueying Yang,Qiaomei Wang,Haiping Shen,Zuoqi Peng,Ya Zhang,Daxun Qi,Ying Yang,Yiping Zhang,Donghai Yan,Xu Ma

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