通过饮食干预调节衰老相关的肠道菌群变化(综述)
  • 老年人的肠道菌群组随年龄增长而变化,并且会受到药物、行动及饮食受限等因素的影响;
  • 衰老表型与肠道菌群组存在双向交互作用,可能进一步导致健康状况的下降;
  • 与补充益生菌/益生元的方式相比,调整膳食习惯更有利于改变肠道菌群结构,从而改善衰老相关疾病;
  • 地中海膳食或许可作为调节肠道菌群进而抵抗衰弱的手段之一,但目前的研究证据力度尚弱;
  • 膳食与生物疗法的组合策略、生酮饮食等替代性方法也值得进一步研究。
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衰老与生理功能衰退及多种疾病相关,衰老相关的肠道菌群变化也可能进一步增加多种疾病的易感性。Current Opinion in Biotechnology上发表的一篇综述文章,详细介绍了衰老表型与肠道菌群变化的双向互作在健康状态逐步衰退中的作用机制,并讨论了通过饮食干预调节菌群以促进健康衰老的可能。
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Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions

了解与年龄相关的肠道菌群变化对慢性疾病的影响及针对老年人饮食干预的前景

10.1016/j.copbio.2020.11.001

2020-12-03, Review

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Ageing is associated with characteristic changes including a gradual decline of physiological functions, inflamm-aging, sarcopenia, and the associated onset of multiple diseases. Another factor potentially contributing to enhanced susceptibility to multiple diseases is aging-associated alteration in the gut microbiome. These alterations include a loss of commensals and gain of disease-associated pathobionts, and are accelerated by lifestyle factors like medication, reduced mobility and restricted diet. Several studies suggest that supplementation or modification of the habitual diet may help to address age-related frailty and comorbidities, aided by microbiota modulation. In this review, we comprehensively summarize recent investigations of microbiota alterations during aging and age-related diseases and the possibilities for altering the microbiome as a therapeutic approach.

First Authors:
Paola Pellanda,Tarini Shankar Ghosh

Correspondence Authors:
Paul W O Toole

All Authors:
Paola Pellanda,Tarini Shankar Ghosh,Paul W O Toole

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