极低卡路里生酮饮食下补充合生制剂或改善减肥效果
创作:szx 审核:szx 2019年07月20日
  • 纳入33名肥胖患者进行一项随机单盲试验,所有患者通过极低卡路里生酮饮食(VLCKD)以及随后的低卡路里饮食(LCD)进行减肥干预;
  • 患者分为3组:补充合生制剂、LCD期间补充合生制剂、补充安慰剂;
  • 合生制剂的补充对患者的肠道菌群多样性无显著影响,但增加了短链脂肪酸产生菌及抗炎症菌(如毛螺菌属);
  • LCD期间补充合生制剂与体重降低相关,并与血糖、C反应蛋白及脂多糖结合蛋白水平的变化相关。
主编推荐语
szx
Molecular Nutrition and Food Research上发表的一项RCT结果,通过极低卡路里生酮饮食进行减肥干预的肥胖患者补充合生制剂后,可改善肠道菌群的组成,降低炎症反应并提升减肥效果。
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Effect of Synbiotic Supplementation in a Very-Low-Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study

极低卡路里生酮饮食下补充合生制剂对减重及肠道菌群的影响:一项初步随机对照研究

10.1002/mnfr.201900167

2019-07-12, Article

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SCOPE: Little is known about the changes that a very-low-calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation.
METHODS AND RESULTS: A randomized, single-blind, parallel-design trial was conducted in 33 obese patients who followed a weight-loss program (PnK-Method) that included a VLCKD followed by a low-calorie diet (LCD). Subjects were randomly allocated to three groups: one supplemented with synbiotics, a second group supplemented with a placebo during the VLCKD and synbiotics during the LCD phase, and a control group given a placebo. Although symbiotic administration did not produce an effect on microbial diversity, an increase in short-chain fatty acid-producing bacteria and anti-inflammatory mediator signals such as Odoribacter and Lachnospira was shown. The administration of Bifidobacterium animalis subsp. lactis and prebiotics fiber during the LCD was significantly associated with the percentage of weight loss and change in glucose, C-reactive protein and lipopolysaccharide-binding protein.
CONCLUSIONS: VLCKD produced important changes in gut microbiota. The administration of synbiotics during VLCKD could improve weight loss through the amelioration of inflammation, which may be mediated by the gut microbiota. This article is protected by copyright. All rights reserved.

First Authors:
Carolina Gutiérrez-Repiso

Correspondence Authors:
Francisco Tinahones

All Authors:
Carolina Gutiérrez-Repiso,Carmen Hernández-García,José Manuel García-Almeida,Diego Bellido,Gracia María Martín-Núñez,Lidia Sánchez-Alcoholado,Juan Alcaide-Torres,Ignacio Sajoux,Francisco Tinahones,Isabel Moreno-Indias

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