益生菌及合生制剂可改善前驱糖尿病
创作:szx 审核:szx 2018年08月08日
  • 120名前驱糖尿病成年患者进行一项随机双盲安慰剂对照试验,患者分别补充多菌种益生菌、基于菊粉的合生制剂、安慰剂;
  • 补充的益生菌中包含冻干的乳杆菌属及双歧杆菌属菌株,合生制剂中包含相同的益生菌及益生元菊粉;
  • 益生菌及合生制剂可显著降低高血糖的发生率,益生菌可显著降低高血压的发生率;
  • 益生菌及合生制剂可显著降低代谢综合征的发病率,益生菌可显著降低HDL胆固醇水平降低的发生率。
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szx
Diabetes and Metabolic Syndrome: Clinical Research and Reviews上发表的一项随机双盲安慰剂对照试验,结果发现补充益生菌及合生制剂可显著改善前驱糖尿病患者的血糖水平及代谢综合征。
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Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: A randomized controlled trial

补充益生菌及合生制剂可改善前驱糖尿病成年人的代谢综合征:一项随机对照试验

10.1016/j.dsx.2018.07.016

2018-07-30, Article

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Aims: Modulation of the gastrointestinal microbiome is suggested to contribute to the progression of metabolic syndrome associated diseases. This study was designed to assess the effects of probiotics and synbiotics on metabolic syndrome in individuals with prediabetes.
Methods: 120 adults with prediabetes were enrolled in a double-blind, placebo-controlled randomized parallel-group clinical trial. Participants were randomized to a multi-species probiotic or inulin-based synbiotic or placebo. Blood samples and anthropometric measures were collected at baseline, 12 and 24 weeks after treatment. The primary outcome measures were the changes between groups in metabolic syndrome and its components' prevalence.
Results: A significant trend for a reduction in the prevalence of hyperglycemia in probiotic and synbiotic groups (p = 0.01 and 0.005 respectively), and hypertension in probiotic group (p = 0.04) was found. The decreases in metabolic syndrome prevalence were significant after taking probiotic and synbiotic supplementation as compared with placebo (p = 0.02). Also, the prevalence of low HDL-cholesterol level was decreased during the study in the probiotic group compared with placebo (p = 0.02).
Conclusions: The potential benefits of using probiotic and synbiotic for metabolic syndrome management in prediabetes have been supported by the results in the current study which might provide an important strategy to combat metabolic syndrome-associated diseases.

First Authors:
Nazila Kassaian

Correspondence Authors:
Masoud Amini

All Authors:
Nazila Kassaian,Awat Feizi,Ashraf Aminorroaya,Masoud Amini

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