摄入全谷物或无法改善肥胖
创作:szx 审核:szx 2019年08月15日
  • 纳入21项随机对照试验(共1798名成年受试者)进行荟萃分析,探究摄入全谷物食品对肥胖相关指标的影响;
  • 在19项研究(共1698名受试者)中,摄入全谷物食品对体重无显著影响;
  • 在10项研究(共769名受试者)中,摄入全谷物食品对BMI无显著影响;
  • 另外,摄入全谷物食品对体脂率、脂肪质量、非脂肪质量、腰围等肥胖相关指标均无显著关联;
  • 需更多研究来确认摄入全谷物食品对肥胖的影响。
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szx
Advances in Nutrition上发表的一项荟萃分析结果,在21项RCT、近2000名受试者中,发现摄入全谷物食品对肥胖相关指标并无改善作用。
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Whole-Grain Consumption Does Not Affect Obesity Measures: An Updated Systematic Review and Meta-analysis of Randomized Clinical Trials

摄入全谷物不影响肥胖指标:一项最新的对随机对照试验的系统性综述及荟萃分析

10.1093/advances/nmz076

2019-08-07, Article

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Since the release of a previous meta-analysis on the effect of whole-grain intake on obesity measures, several clinical trials have been published. Therefore, we aimed to update the previous meta-analysis on the effect of whole-grain intake on obesity measures by including recently published studies, as well as considering the main limitations in that analysis. We searched the online databases of PubMed, Scopus, Clarivate Web of Science, EmBase, and Google Scholar for relevant studies published up to February 2019, using relevant keywords. Randomized clinical trials investigating the effect of whole-grain products or diets high in whole-grain foods, compared with a control diet, on anthropometric measures [including body weight, BMI, waist circumference, and fat mass (FM)] were included. In total, 21 studies with a total sample of 1798 participants, aged ≥18 years, were considered. Based on 22 effect sizes from 19 studies on body weight, with a total sample of 1698 adults, we found no significant effect of whole-grain consumption on body weight. The same findings were obtained for BMIs, such that using 10 effect sizes from 10 clinical trials with a total sample of 769 individuals we did not find any significant effect. With regards to body fat percentage [weighted mean difference (WMD): 0.27; 95% CI: -0.05 to 0.58%; P = 0.09], FM (WMD: 0.45; 95% CI: -0.12 to 1.02 kg; P = 0.12), fat-free mass (WMD: 0.31; 95% CI: -0.67 to 0.06 kg; P = 0.10), and waist circumference (WMD: 0.06; 95% CI: -0.50 to 0.63 cm; P = 0.82), we failed to find any significant effect of whole-grain consumption. In conclusion, our findings did not support current recommendations of whole-grain intake in attempts to control obesity measures. Given the beneficial effects of whole-grain intake on other measures of human health, additional well-designed studies are required to further investigate the effect on obesity. The protocol has been registered with PROSPERO (registration number CRD42018089176).

First Authors:
Omid Sadeghi

Correspondence Authors:
Ahmad Esmaillzadeh

All Authors:
Omid Sadeghi,Mehdi Sadeghian,Sepideh Rahmani,Vahid Maleki,Bagher Larijani,Ahmad Esmaillzadeh

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