长双歧杆菌或可降低肥胖/超重个体的空腹血糖
创作:nana 审核:nana 2020年12月26日
  • 长双歧杆菌APC1472干预高脂诱导的肥胖小鼠16周,能减轻肥胖小鼠体重及脂肪堆积,改善糖耐量、瘦素和皮质酮水平,诱导肥胖小鼠下丘脑神经肽表达变化;
  • 122名肥胖或超重的志愿者,随机分两组,分别接受长双歧杆菌APC1472或安慰剂干预12周,发现长双歧杆菌APC1472能改善空腹血糖,及肥胖者的胃饥饿素和皮质醇觉醒反应;
  • 长双歧杆菌APC1472可以增加双歧杆菌丰度,但不改变人肠道菌群结构、BMI和W/H比值及脂质和炎症水平。
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nana
肠道菌群与个体肥胖密切相关,研究表明某些益生菌已经显示出抗肥胖的效果。 EBioMedicine发表的研究,评价了长双歧杆菌APC1472株(长双歧杆菌APC1472)在高脂饮食诱导的肥胖小鼠中是否有抗肥胖作用,以及补充长双歧杆菌APC1472是否能降低健康超重/肥胖个体的体重指数(BMI)。结果表明,长双歧杆菌APC1472能降低肥胖小鼠体重,并且在临床研究中能改善受试者的空腹血糖水平。本研究结果提示长双歧杆菌APC1472诱导的空腹血糖下降可能对糖尿病人群具有重要的临床健康意义。
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EBioMedicine [IF:5.736]

Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human

长双歧杆菌对抗肥胖:从啮齿动物到人类的部分成功转化

10.1016/j.ebiom.2020.103176

2020-12-18, Article

Abstract & Authors:展开

Abstract:收起
Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes.
Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention.
Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]).
Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity.
Funding: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.

First Authors:
Harriët Schellekens,Cristina Torres-Fuentes,Marcel van de Wouw

Correspondence Authors:
Harriët Schellekens,John F Cryan

All Authors:
Harriët Schellekens,Cristina Torres-Fuentes,Marcel van de Wouw,Caitriona M Long-Smith,Avery Mitchell,Conall Strain,Kirsten Berding,Thomaz Fs Bastiaanssen,Kieran Rea,Anna V Golubeva,Silvia Arboleya,Mathieu Verpaalen,Matteo M Pusceddu,Amy Murphy,Fiona Fouhy,Kiera Murphy,Paul Ross,Bernard L Roy,Catherine Stanton,Timothy G Dinan,John F Cryan

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抗代谢综合征关键肠菌——长双歧杆菌APC1472

林佑,2021-01-08

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