出生方式和地点塑造婴儿肠道菌群,可能影响肠屏障和免疫功能
  • 分析180名健康婴儿生命早期的肠道菌群,发现出生地点和分娩方式影响肠道菌群组成;
  • 与在医院出生相比,在家出生(HB)的婴儿的菌群丰富度和多样性以及变形菌的相对丰度都较低;
  • 剖腹产(CS)婴儿中,拟杆菌门和双歧杆菌属降低,且18月龄时有较高的BMI和体重/身长比值;
  • 体外肠道模型中,与CS婴儿相比,HB婴儿的粪菌上清液能更好的刺激肠上皮的成熟和屏障功能,增加免疫反应(TLR4途径活化和促炎细胞因子释放)。
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生命早期的肠道菌群受多种围产期因素的影响,Microbiome发表的一项新研究表明,出生地点(医院vs在家)和分娩方式(剖腹产vs顺产)对婴儿早期的肠道菌群组成有很强的塑造作用,并在体外模型中分析了菌群差异对肠上皮功能和免疫反应的影响。
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Microbiome [IF:11.607]

Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function

围产期环境塑造菌群定植和婴儿生长:对宿主反应和肠道功能的影响

10.1186/s40168-020-00940-8

2020-11-23, Article

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Background: Early microbial colonization triggers processes that result in intestinal maturation and immune priming. Perinatal factors, especially those associated with birth, including both mode and place of delivery are critical to shaping the infant gut microbiota with potential health consequences.
Methods: Gut microbiota profile of 180 healthy infants (n = 23 born at home and n = 157 born in hospital, 41.7% via cesarean section [CS]) was analyzed by 16S rRNA gene sequencing at birth, 7 days, and 1 month of life. Breastfeeding habits and infant clinical data, including length, weight, and antibiotic exposure, were collected up to 18 months of life. Long-term personalized in vitro models of the intestinal epithelium and innate immune system were used to assess the link between gut microbiota composition, intestinal function, and immune response.
Results: Microbiota profiles were shaped by the place and mode of delivery, and they had a distinct biological impact on the immune response and intestinal function in epithelial/immune cell models. Bacteroidetes and Bifidobacterium genus were decreased in C-section infants, who showed higher z-scores BMI and W/L during the first 18 months of life. Intestinal simulated epithelium had a stronger epithelial barrier function and intestinal maturation, alongside a higher immunological response (TLR4 route activation and pro-inflammatory cytokine release), when exposed to home-birth fecal supernatants, compared with CS. Distinct host response could be associated with different microbiota profiles.
Conclusions: Mode and place of birth influence the neonatal gut microbiota, likely shaping its interplay with the host through the maturation of the intestinal epithelium, regulation of the intestinal epithelial barrier, and control of the innate immune system during early life, which can affect the phenotypic responses linked to metabolic processes in infants.

First Authors:
M Selma-Royo

Correspondence Authors:
M C Collado

All Authors:
M Selma-Royo,M Calatayud Arroyo,I García-Mantrana,A Parra-Llorca,R Escuriet,C Martínez-Costa,M C Collado

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