国内团队:粪菌移植或能改善脊髓损伤
创作:mildbreeze 审核:mildbreeze 03月11日
  • 脊髓损伤(SCI)小鼠接受来自健康小鼠的粪菌移植(FMT)后,神经轴突再生、体重增长、代谢谱、肠屏障完整性和胃肠转运都得到了改善;
  • SCI小鼠中,厚壁菌门、Christensenellaceae菌科和Butyricimonas菌属减少,FMT重塑了肠道菌群并使这些菌得到恢复;
  • FMT使菌群代谢物SCFA水平升高,与肠道通透性和运动机能的恢复相关;
  • FMT可能通过下调脊髓的IL-1β/NF-κB信号和肠道的NF-κB信号,缓解SCI小鼠的神经和肠道炎症。
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mildbreeze
脊髓损伤(SCI)患者存在肠道菌群紊乱,这反过来可能加剧了神经损伤。北京脑重大疾病研究院陈志国、李建军、于艳与研究团队近期在Microbiome发表成果,在小鼠模型中研究了粪菌移植(FMT)用于治疗SCI的潜力,表明FMT可重塑肠道菌群,通过提升短链脂肪酸水平促进抗炎作用,从而增强SCI小鼠的神经再生、改善运动机能和胃肠功能,为临床治疗SCI提供了新思路。
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Microbiome [IF:11.607]

Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis

粪菌移植对脊髓损伤小鼠模型神经功能恢复的影响:脑-肠轴参与其中

10.1186/s40168-021-01007-y

03-07, Article

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Background: Spinal cord injury (SCI) patients display disruption of gut microbiome, and gut dysbiosis exacerbate neurological impairment in SCI models. Cumulative data support an important role of gut microbiome in SCI. Here, we investigated the hypothesis that fecal microbiota transplantation (FMT) from healthy uninjured mice into SCI mice may exert a neuroprotective effect.
Results: FMT facilitated functional recovery, promoted neuronal axonal regeneration, improved animal weight gain and metabolic profiling, and enhanced intestinal barrier integrity and GI motility in SCI mice. High-throughput sequencing revealed that levels of phylum Firmicutes, family Christensenellaceae, and genus Butyricimonas were reduced in fecal samples of SCI mice, and FMT remarkably reshaped gut microbiome. Also, FMT-treated SCI mice showed increased amount of fecal short-chain fatty acids (SCFAs), which correlated with alteration of intestinal permeability and locomotor recovery. Furthermore, FMT downregulated IL-1β/NF-κB signaling in spinal cord and NF-κB signaling in gut following SCI.
Conclusion: Our study demonstrates that reprogramming of gut microbiota by FMT improves locomotor and GI functions in SCI mice, possibly through the anti-inflammatory functions of SCFAs.

First Authors:
Yingli Jing,Fan Bai

Correspondence Authors:
Yan Yu,Jianjun Li,Zhiguo Chen

All Authors:
Yingli Jing,Yan Yu,Fan Bai,Limiao Wang,Degang Yang,Chao Zhang,Chuan Qin,Mingliang Yang,Dong Zhang,Yanbing Zhu,Jianjun Li,Zhiguo Chen

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梅斯医学新闻网站

Microbiome:粪菌移植促进神经功能恢复

2021-03-10

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