肠道菌群特征或可预测益生元干预的减肥效果
创作:徐笑 审核:兵兵 03月01日
  • 取4个肥胖供体粪便菌群接种到抗生物素处理的人源性肥胖小鼠体内,高脂饲料喂养+菊粉处理;
  • 巴恩斯氏菌、嗜胆菌、丁酸单胞菌、食物谷菌、梭菌XIVa、Akk菌、拉乌尔菌和布劳特式菌等菌属,与菊粉改善代谢和胰岛素敏感性、降低肝脏脂质积累有关;
  • 纳入106人进行3个月菊粉补充研究,肥胖患者干预前的厌氧棒状菌、Akk菌和丁酸球菌等菌属的水平,驱动了菊粉应答者的BMI降低;
  • 补充益生元前对肠道菌群进行表征有助于区分应答者和非应答者。
主编推荐语
兵兵
Gut上发表的这项来自比利时的研究,结合动物和人群实验发现,菊粉对于肥胖的改善效果与干预前的肠道菌群组成密切相关,主要体现在菌群中特定微生物类群的含量上。因此,在干预前对受试者的肠道菌群进行分析,或能筛选出潜在的应答者,有助于实现个性化减肥。
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Gut [IF:19.819]

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

发现驱动肥胖患者益生元干预有效性的肠道微生物特征

10.1136/gutjnl-2019-319726

02-10, Article

Abstract & Authors:展开

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Objective: The gut microbiota has been proposed as an interesting therapeutic target for metabolic disorders. Inulin as a prebiotic has been shown to lessen obesity and related diseases. The aim of the current study was to investigate whether preintervention gut microbiota characteristics determine the physiological response to inulin.
Design : The stools from four obese donors differing by microbial diversity and composition were sampled before the dietary intervention and inoculated to antibiotic-pretreated mice (hum-ob mice; humanised obese mice). Hum-ob mice were fed with a high-fat diet and treated with inulin. Metabolic and microbiota changes on inulin treatment in hum-ob mice were compared with those obtained in a cohort of obese individuals supplemented with inulin for 3 months.
Results : We show that hum-ob mice colonised with the faecal microbiota from different obese individuals differentially respond to inulin supplementation on a high-fat diet. Among several bacterial genera, Barnesiella, Bilophila, Butyricimonas, Victivallis, Clostridium XIVa, Akkermansia, Raoultella and Blautia correlated with the observed metabolic outcomes (decrease in adiposity and hepatic steatosis) in hum-ob mice. In addition, in obese individuals, the preintervention levels of Anaerostipes, Akkermansia and Butyricicoccus drive the decrease of body mass index in response to inulin.
Conclusion : These findings support that characterising the gut microbiota prior to nutritional intervention with prebiotics is important to increase the positive outcome in the context of obesity and metabolic disorders.

First Authors:
Julie Rodriguez

Correspondence Authors:
Nathalie M Delzenne

All Authors:
Julie Rodriguez,Sophie Hiel,Audrey Neyrinck,Tiphaine Le Roy,Sarah A Pötgens,Quentin Leyrolle,Barbara D Pachikian,Marco A Gianfrancesco,Patrice D Cani,Nicolas Paquot,Miriam Cnop,Nicolas Lanthier,Jean-Paul Thissen,Laure B Bindels,Nathalie M Delzenne

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Gut Microbiota for Health新闻网站

Baseline gut microbiota may determine inulin effects on weight loss

2020-03-16

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