儿童期饮食与炎症水平与未来抑郁症风险存在关联
  • 纳入6939名平均8.5岁的儿童,调查其饮食结构,并在9.5岁时检测C反应蛋白和IL-6的水平,依此计算炎症饮食评分(IDP);
  • 随访十年后这些参与者患抑郁症的风险;
  • 初步上看,IDP三分位后,最高组相较于最低组,抑郁症风险增高1.34倍;
  • 但若调整所有潜在混在因素后,该关联无统计学意义;
  • 在正常BMI人群中,IDP评分与抑郁症风险呈正相关,但在超重/肥胖人群中无统计学关联;
  • 该研究初步提示儿童期饮食炎症情况与未来抑郁症风险存在关联。
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本研究利用队列研究数据,发现在儿童期8-9岁时的饮食结构以及体内炎症因子水平与10年后患抑郁症的风险存在关联。该研究计算的IDP评分值得关注并进一步探索。
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The Relationship between Inflammatory Dietary Pattern in Childhood and Depression in Early Adulthood

儿童期炎症饮食模式与成年期抑郁的关系

10.1016/j.bbih.2019.100017

2019-12-15, Article

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Background: Inflammation may be a hidden process in the relationship between dietary intake and depression, but no study has evaluated the role of diet and inflammation jointly in explaining depression risk in early life. The current study aims to investigate the relationship between inflammatory dietary pattern (IDP) in childhood and depression in early adulthood.
Methods: This study used data prospectively collected over 10 years from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (n=6939) free from depression at baseline (age 8.5 years). An IDP score was empirically derived via reduced rank regression and stepwise linear regression based on dietary intake data from the food frequency questionnaire at 8.5 years and levels of inflammatory biomarkers, C-reactive protein and interleukin-6, at 9.5 years. At age 18 years, depression cases were identified via the International Statistical Classification of Diseases, 10th Revision (ICD-10) diagnosis and the Clinical Interview Schedule-Revised (CIS-R) depression score. Logistic regression models were constructed to examine the relationship between the IDP score and risk of depression adjusted for potential confounders. Analyses stratified by weight status were also conducted. Multiple imputations were utilized to minimize bias due to loss-to-follow-up.
Results: Participants in the highest tertile of IDP score had 1.34 times odds to develop depression compared to those in the lowest tertile (95% CI, 1.08-1.66; P-trend<0.01), after dietary misreporting status and energy intake were adjusted. After all covariates were adjusted, the relationship between IDP tertiles and depression was attenuated (highest tertile vs. lowest tertile: OR=1.21; 95% CI, 0.96-1.51); in addition, the relationship was marginally significant among participants who were not overweight or obese (p<0.10) but not significant among participants who were overweight or obese.
Conclusions: Higher IDP in childhood seems to be associated with higher depression risk in early adulthood. The study provides preliminary evidence that chronic inflammation may underlie the relationship between diet and depression even for children, especially those who are not overweight or obese.

All Authors:
Xiao Cong,Melissa Tracy,Lynn S Edmunds,Akiko S Hosler,Allison A Appleton

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