Cell子刊:菌群干预或能影响对霍乱疫苗的免疫应答
创作:orchid 审核:兵兵 2020年05月12日
  • 移植了营养不良儿童的菌群的小鼠对霍乱疫苗(CT)反应不同,且CT-IgA应答的增强并不伴随着响应(R)菌群中细菌的粘膜IgA靶向性的改变;
  • 具有低响应(HypoR)菌群的小鼠与R小鼠共居,可以改善小鼠的CT反应;
  • 补充由螺旋藻、苋菜、亚麻籽和微量营养素组成的营养品,增强CT-IgA的产生,改善限菌小鼠对口服CT的多种疫苗反应;
  • 补充由5种培养菌组成的菌群+上述营养素,改善HypoR小鼠的CT反应;
  • 菌群和营养素影响小鼠对CT的免疫反应。
主编推荐语
兵兵
《Cell Host and Microbe》近期发表了来自Jeffrey Gordon团队的研究。研究者将营养不良儿童的菌群移植给无菌小鼠,发现小鼠对霍乱疫苗(CT)反应不同:有些菌群响应CT,有些则对CT呈现低响应。将移植了响应和低响应菌群的小鼠进行共居饲养,发现低响应小鼠对CT的响应情况得到改善。并且,螺旋藻、苋菜、亚麻籽和微量营养素组成的营养品的干预可以改善小鼠对CT的免疫应答。同时,同时利用益生菌和营养素干预,小鼠的CT响应增强。该研究为临床前期膳食和益生菌改善免疫应答提供依据。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Combined Prebiotic and Microbial Intervention Improves Oral Cholera Vaccination Responses in a Mouse Model of Childhood Undernutrition

益生菌和微生物联合干预改善儿童营养不良小鼠模型口服霍乱疫苗的免疫应答

10.1016/j.chom.2020.04.008

2020-04-28, Article

Abstract & Authors:展开

Abstract:收起
Undernourished children in low-income countries often exhibit poor responses to oral vaccination. Perturbed microbiota development is linked to undernutrition, but whether and how microbiota changes affect vaccine responsiveness remains unclear. Here, we show that gnotobiotic mice colonized with microbiota from undernourished Bangladeshi children and fed a Bangladeshi diet exhibited microbiota-dependent differences in mucosal IgA responses to oral vaccination with cholera toxin (CT). Supplementation with a nutraceutical consisting of spirulina, amaranth, flaxseed, and micronutrients augmented CT-IgA production. Mice initially colonized with a microbiota associated with poor CT responses exhibited improved immunogenicity upon invasion of bacterial taxa from cagemates colonized with a more “responsive” microbiota. Additionally, a consortium of five cultured bacterial invaders conferred augmented CT-IgA responses in mice fed the supplemented diet and colonized with the “hypo-responsive” community. These results provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.

First Authors:
Blanda Di Luccia,Philip P Ahern,Nicholas W Griffin

Correspondence Authors:
Jeffrey I Gordon

All Authors:
Blanda Di Luccia,Philip P Ahern,Nicholas W Griffin,Jiye Cheng,Janaki L Guruge,Alexandra E Byrne,Dmitry A Rodionov,Semen A Leyn,Andrei L Osterman,Tahmeed Ahmed,Marco Colonna,Michael J Barratt,Nicolas F Delahaye,Jeffrey I Gordon

图片
Cell Host and Microbe期刊

Nourishing the Microbiota to Promote Mucosal Immunity

2020-06-10

评论