补充混合益生菌,可改善抗生素治疗和剖腹产婴儿的肠道菌群
  • 一项双盲随机对照试验中,400对母婴分为2组,益生菌组母亲(孕期)和婴儿均补充混合益生菌,对照组补充安慰剂;
  • 婴儿3月龄的粪便菌群分析显示,补充益生菌在整体上影响菌群组成,但效果取决于喂养方式,仅母乳喂养婴儿发生双歧杆菌增多、变形菌门和梭菌纲减少;
  • 安慰剂组中,分娩方式和抗生素使用均与菌群组成和功能改变显著相关,尤其是双歧杆菌属丰度降低,而这些影响在益生菌组中被完全消除或减弱。
主编推荐语
mildbreeze
剖腹产和早期抗生素使用,影响婴儿正常的肠道菌群建立,可对健康产生长期潜在危害。Microbiome近期发表一项临床试验,发现给怀孕母亲及其婴儿补充含有4种市售益生菌株(短双歧杆菌Bb99、费氏丙酸杆菌舍氏亚种JS、鼠李糖乳杆菌Lc705、鼠李糖乳杆菌GG)的混合益生菌,搭配母乳喂养,可修正或改善抗生素治疗或剖腹产对婴儿肠道菌群造成的不良影响。这些发现或有临床应用价值,值得专业人士关注。
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Microbiome [IF:11.607]

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

补充益生菌使经抗生素治疗和剖腹产婴儿的肠道菌群组成和功能恢复正常

10.1186/s40168-018-0567-4

2018-10-16, Article

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BACKGROUND: Infants born by caesarean section or receiving antibiotics are at increased risk of developing metabolic, inflammatory and immunological diseases, potentially due to disruption of normal gut microbiota at a critical developmental time window. We investigated whether probiotic supplementation could ameliorate the effects of antibiotic use or caesarean birth on infant microbiota in a double blind, placebo-controlled randomized clinical trial. Mothers were given a multispecies probiotic, consisting of Bifidobacterium breve Bb99 (Bp99 2 × 10 cfu) Propionibacterium freundenreichii subsp. shermanii JS (2 × 10cfu), Lactobacillus rhamnosus Lc705 (5 × 10 cfu) and Lactobacillus rhamnosus GG (5 × 10 cfu) (N = 168 breastfed and 31 formula-fed), or placebo supplement (N = 201 breastfed and 22 formula-fed) during pregnancy, and the infants were given the same supplement. Faecal samples of the infants were collected at 3 months and analyzed using taxonomic, metagenomic and metaproteomic approaches.
RESULTS: The probiotic supplement had a strong overall impact on the microbiota composition, but the effect depended on the infant's diet. Only breastfed infants showed the expected increase in bifidobacteria and reduction in Proteobacteria and Clostridia. In the placebo group, both birth mode and antibiotic use were significantly associated with altered microbiota composition and function, particularly reduced Bifidobacterium abundance. In the probiotic group, the effects of antibiotics and birth mode were either completely eliminated or reduced.
CONCLUSIONS: The results indicate that it is possible to correct undesired changes in microbiota composition and function caused by antibiotic treatments or caesarean birth by supplementing infants with a probiotic mixture together with at least partial breastfeeding.
TRIAL REGISTRATION: clinicaltrials.gov NCT00298337 . Registered March 2, 2006.

First Authors:
Katri Korpela

Correspondence Authors:
Katri Korpela

All Authors:
Katri Korpela,Anne Salonen,Outi Vepsäläinen,Marjo Suomalainen,Carolin Kolmeder,Markku Varjosalo,Sini Miettinen,Kaarina Kukkonen,Erkki Savilahti,Mikael Kuitunen,Willem M De Vos

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