Science:靶向免疫细胞治疗高血压
创作:szx 审核:szx 2018年03月29日
  • 免疫系统在高血压中起到关键作用,一些研究提示免疫细胞可使啮齿动物,甚至是人体的血压升高;
  • 活化的免疫细胞可损伤肾脏及血管内壁,从而造成血压的升高;
  • 例如在肾脏中,免疫细胞促进钠离子的滞留,后者可起到生压作用;
  • 调节性T细胞可减少小鼠的血管损伤并降低血压;
  • 鉴定出一种化合物——2-HOBA,可阻断氧化脂质对蛋白的损伤及对免疫细胞的活化,从而抑制小鼠体内因免疫细胞造成的高血压。
主编推荐语
szx
免疫细胞的活化可能促进高血压,一种可抑制免疫细胞活化的新化合物——2-HOBA或可作为治疗高血压的新药,研究者们正在期待临床试验的开展。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Science [IF:41.845]

Restraining immunity could lower high blood pressure

抑制免疫反应可能缓解高血压

10.1126/science.359.6379.966

2018-03-02, Other

Abstract & Authors:展开

Abstract:收起
The immune system is an underappreciated culprit in hypertension. Numerous studies suggest that immune cells increase blood pressure in rodents, and some evidence suggests they do the same in people. Activated immune cells harm the kidneys and the lining of the blood vessels, causing changes that increase blood pressure. In the kidneys, for instance, the cells promote the retention of sodium, which boosts blood pressure. Researchers have identified a compound, 2-HOBA, that curbs immune cells' effects on blood pressure in mice with hypertension. 2-HOBA blocks the effects of oxidized lipids that can damage proteins and activate immune cells. Researchers hope to begin a clinical trial of the compound in people.

First Authors:
Mitch Leslie

Correspondence Authors:
Mitch Leslie

All Authors:
Mitch Leslie

评论