母乳中的环境污染物影响婴儿肠道菌群
  • 纳入267对母婴,发现母乳中检测到的多溴联苯醚-28(PBDE-28)和全氟辛烷磺酸(PFOS)与1月龄婴儿较低的肠道菌群多样性相关;
  • 在有毒物质暴露相对较高的婴儿中,乳杆菌属的相对丰度较低;
  • 母乳中的有毒物质影响婴儿菌群功能, PBDE-28、多氯联二苯-209(PCB-209)分别与粪便丙酸、乙酸含量较低相关,全氟辛酸(PFOA)、二噁英样PCB-167分别与丙酸、乙酸含量较高相关;
  • 环境有毒物质是否对婴儿健康产生影响有待进一步研究分析。
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来自《Microbiome》上的一项研究,发现母乳中的一些环境污染物会影响后代婴儿的肠道菌群组成及代谢产物水平。该结果对阐释环境污染物对婴儿健康的长期影响具有参考价值。
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Microbiome [IF:11.607]

Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month

挪威母亲母乳中的环境有毒物质与其1月龄婴儿的肠道菌群组成和代谢的关系

10.1186/s40168-019-0645-2

2019-02-27, Article

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BACKGROUND: Early disruption of the microbial community may influence life-long health. Environmental toxicants can contaminate breast milk and the developing infant gut microbiome is directly exposed. We investigated whether environmental toxicants in breastmilk affect the composition and function of the infant gut microbiome at 1 month. We measured environmental toxicants in breastmilk, fecal short-chain fatty acids (SCFAs), and gut microbial composition from 16S rRNA gene amplicon sequencing using samples from 267 mother-child pairs in the Norwegian Microbiota Cohort (NoMIC). We tested 28 chemical exposures: polychlorinated biphenyls (PCBs), polybrominated flame retardants (PBDEs), per- and polyfluoroalkyl substances (PFASs), and organochlorine pesticides. We assessed chemical exposure and alpha diversity/SCFAs using elastic net regression modeling and generalized linear models, adjusting for confounders, and variation in beta diversity (UniFrac), taxa abundance (ANCOM), and predicted metagenomes (PiCRUSt) in low, medium, and high exposed groups.
RESULTS: PBDE-28 and the surfactant perfluorooctanesulfonic acid (PFOS) were associated with less microbiome diversity. Some sub-OTUs of Lactobacillus, an important genus in early life, were lower in abundance in samples from infants with relative "high" (> 80th percentile) vs. "low" (< 20th percentile) toxicant exposure in this cohort. Moreover, breast milk toxicants were associated with microbiome functionality, explaining up to 34% of variance in acetic and propionic SCFAs, essential signaling molecules. Per one standard deviation of exposure, PBDE-28 was associated with less propionic acid (- 24% [95% CI - 35% to - 14%] relative to the mean), and PCB-209 with less acetic acid (- 15% [95% CI - 29% to - 0.4%]). Conversely, PFOA and dioxin-like PCB-167 were associated with 61% (95% CI 35% to 87%) and 22% (95% CI 8% to 35%) more propionic and acetic acid, respectively.
CONCLUSIONS: Environmental toxicant exposure may influence infant gut microbial function during a critical developmental window. Future studies are needed to replicate these novel findings and investigate whether this has any impact on child health.

First Authors:
Nina Iszatt

Correspondence Authors:
Merete Eggesbø

All Authors:
Nina Iszatt,Stefan Janssen,Virissa Lenters,Cecilie Dahl,Hein Stigum,Rob Knight,Siddhartha Mandal,Shyamal Peddada,Antonio Gonzalez,Tore Midtvedt,Merete Eggesbø

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