菊粉或可改善肥胖患者情绪
创作:楸楸 审核:兵兵 02月21日
  • 纳入106名肥胖患者,分为益生元与安慰剂2组,即分别接受每天16g的天然菊粉或麦芽糊精,食用富含或少含菊粉的蔬菜3个月并限制热量摄入;
  • 菊粉干预可适度改善肥胖受试者的情绪和认知;
  • 具有较高初始粪球菌水平的肥胖患者更可能受益于菊粉摄入对情绪的改善;
  • 具有较差的初始代谢和炎症特征(IL-8水平,胰岛素抵抗和肥胖)的肥胖患者,也更容易感应菊粉摄入对情绪的改善;
  • 菊粉可以改善携带特定肠道菌群的肥胖患者的情绪。
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兵兵
一项随机单盲多中心安慰剂对照试验,文章研究了菊粉的摄入对肥胖患者认知和情绪的影响。研究结果显示,菊粉(益生元)的摄入,可以对具有特定初始身体状态的肥胖患者情绪有一定改善作用。本研究显示,一些肠道菌群、代谢物或者炎症因子可能参与介导菊粉对肥胖相关行为的改善。
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Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial

益生元对肥胖患者情绪的影响取决于初始肠道菌群组成:一项随机对照试验

10.1016/j.bbi.2021.01.014

01-28, Article

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Background and aims: Metabolic and behavioral diseases, which are often related to obesity, have been associated to alterations of the gut microbiota considered as an interesting therapeutic target. We have analyzed in a cohort of obese patients treated with prebiotic inulin versus placebo the potential link between gut microbiota changes occurring upon intervention and their effect on psychological parameters (mood and cognition).
Methods: A randomized, single-blinded, multicentric, placebo-controlled trial was conducted in 106 obese patients assigned to two groups: prebiotic versus placebo, who received respectively 16 g/d of native inulin or maltodextrin combined with dietary advice to consume inulin-rich or -poor vegetables for 3 months as well as to restrict caloric intake. Anthropometric measurements, food intake, psychological questionnaires, serum measures, and fecal microbiome sequencing were performed before and after the intervention.
Results: Inulin supplementation in obese subjects had moderate beneficial effect on emotional competence and cognitive flexibility. However, an exploratory analysis revealed that some patients exhibiting specific microbial signature -elevated Coprococcus levels at baseline- were more prone to benefit from prebiotic supplementation in terms of mood. Positive responders toward inulin intervention in term of mood also displayed worse metabolic and inflammatory profiles at baseline (increased levels of IL-8, insulin resistance and adiposity).
Conclusion: This study shows that inulin intake can be helpful to improve mood in obese subjects exhibiting a specific microbial profile. The present work highlights some microbial, metabolic and inflammatory features (IL-8, insulin resistance) which can predict or mediate the beneficial effects of inulin on behaviour in obesity.

First Authors:
Quentin Leyrolle,Renata Cserjesi

Correspondence Authors:
Olivier Klein,Olivier Luminet,Nathalie M Delzenne

All Authors:
Quentin Leyrolle,Renata Cserjesi,Maria DGH Mulders,Giorgia Zamariola,Sophie Hiel,Marco A Gianfrancesco,Daphné Portheault,Camille Amadieu,Laure B Bindels,Sophie Leclercq,Julie Rodriguez,Audrey Neyrinck,Patrice D Cani,Nicolas Lanthier,Pierre Trefois,Jerome Bindelle,Nicolas Paquot,Miriam Cnop,Jean-Paul Thissen,Olivier Klein,Olivier Luminet,Nathalie M Delzenne

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