西农+华大NC新文:轻断食调节“菌群-代谢物-脑”轴,减少糖尿病脑损伤
创作:mildbreeze 审核:mildbreeze 03月01日
  • 2型糖尿病小鼠进行28天间歇性禁食(IF),不仅改善了代谢表型,还经菌群-代谢物-脑轴发挥了神经保护作用,改善行为障碍;
  • IF可增强大脑海马中的线粒体生成和能量代谢基因表达,改变肠道菌群组成,改善与认知功能相关的菌群代谢物水平;
  • 鉴定出IF相关的菌群、代谢物和大脑基因表达之间的多个关联;
  • 肠道菌群部分介导IF的神经保护作用,补充3-吲哚丙酸、5-羟色胺、短链脂肪酸或牛磺熊去氧胆酸等菌群代谢物也可改善糖尿病小鼠认知功能。
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mildbreeze
2型糖尿病(T2D)可引起多种并发症,包括认知衰退等神经疾病。间歇性禁食(IF)是一种周期性的禁食方法,可有效改善代谢,减轻胰岛素抵抗等T2D症状,在一些动物模型中也显示出神经保护和改善认知的作用,但IF对T2D相关认知障碍的影响仍不清楚。Nature Communications最新发表了西北农林科技大学刘学波团队、深圳华大农业应用研究院赵山岑团队与瑞典查尔姆斯理工大学施琳等的合作研究,西北农林科技大学刘志刚和华大代晓霜为共同第一作者。该研究通过多组学技术(肠道菌群、血浆代谢组、大脑转录组)结合行为测试等方法,综合分析了IF对T2D模型小鼠的认知损伤的影响和机制。研究表明,IF引起的小鼠肠道菌群结构和菌群代谢产物改变,可增强大脑海马的线粒体生成和能量代谢、保护神经突触结构,从而减轻糖尿病小鼠的认知和空间记忆障碍。这种“肠道菌群-代谢物-脑”轴的神经保护机制,为调节肠道菌群改善代谢相关的神经退行性疾病带来了新启示。
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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

肠道菌群介导间歇性禁食对糖尿病诱导的认知损伤的缓解作用

10.1038/s41467-020-14676-4

02-18, Article

Abstract & Authors:展开

Abstract:收起
Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.

First Authors:
Zhigang Liu,Xiaoshuang Dai

Correspondence Authors:
Zhigang Liu,Lin Shi,Shancen Zhao,Xuebo Liu

All Authors:
Zhigang Liu,Xiaoshuang Dai,Hongbo Zhang,Renjie Shi,Yan Hui,Xin Jin,Wentong Zhang,Luanfeng Wang,Qianxu Wang,Danna Wang,Jia Wang,Xintong Tan,Bo Ren,Xiaoning Liu,Tong Zhao,Jiamin Wang,Junru Pan,Tian Yuan,Chuanqi Chu,Lei Lan,Fei Yin,Enrique Cadenas,Lin Shi,Shancen Zhao,Xuebo Liu

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华大科技BGITech

间歇性禁食防变傻 !Nature Communications 揭示间歇性禁食预防糖尿病脑损伤机制

2020-02-18

点评:深圳华大农业应用研究院代晓霜博士(本文共同第一作者)撰写的解读文章。

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