Nature子刊:链球菌属与膝关节炎症及膝盖疼痛相关
创作:爱的抉择 审核:szx 2019年11月05日
  • 纳入鹿特丹研究中的1427名受试者,发现链球菌属的丰度升高与骨关节炎(OA)相关的膝盖疼痛严重程度增加显著相关;
  • 校正口服药物(质子泵抑制剂或非甾体类抗炎药,两者均可能改变肠道菌群组成)的因素后,链球菌属仍与OA相关膝盖疼痛严重程度显著相关;
  • 纳入Lifelines-DEEP研究的867名受试者进行验证,确认链球菌属的丰度与OA相关膝盖疼痛严重程度显著相关;
  • 高丰度的链球菌属和膝关节的局部炎症增加(表现为膝关节渗出增加)相关。
主编推荐语
szx
肠道菌群产生的内毒素可能刺激巨噬细胞以产生炎症,导致关节炎相关疼痛。Nature Communications上发表的一项最新研究,在2个不同队列研究中均发现,骨关节炎患者的膝盖疼痛程度与肠道菌群中链球菌属的丰度显著相关,而链球菌属丰度的增加与膝关节炎症显著相关。
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Intestinal microbiome composition and its relation to joint pain and inflammation

肠道菌群组成与关节痛及炎症的关系

10.1038/s41467-019-12873-4

2019-10-25, Article

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Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

First Authors:
Cindy G Boer

Correspondence Authors:
Joyce BJ van Meurs

All Authors:
Cindy G Boer,Djawad Radjabzadeh,Carolina Medina-Gomez,Sanzhima Garmaeva,Dieuwke Schiphof,Pascal Arp,Thomas Koet,A Kurilshikov,Jingyuan Fu,M Arfan Ikram,Sita Bierma-Zeinstra,André G Uitterlinden,Robert Kraaij,Alexandra Zhernakova,Joyce BJ van Meurs

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Nature Reviews Rheumatology期刊

Gut microbiome linked with OA knee pain

Sarah Onuora,2019-11-29

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