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Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.
Cindy G Boer
Joyce BJ van Meurs
Cindy G Boer,Djawad Radjabzadeh,Carolina Medina-Gomez,Sanzhima Garmaeva,Dieuwke Schiphof,Pascal Arp,Thomas Koet,A Kurilshikov,Jingyuan Fu,M Arfan Ikram,Sita Bierma-Zeinstra,André G Uitterlinden,Robert Kraaij,Alexandra Zhernakova,Joyce BJ van Meurs