鼻子里的核心菌群长啥样?
  • 采用16S rRNA测序和标准化方法,分析9个国家14个地区410人的鼻窦菌群;
  • 尽管存在个体间差异性,但在健康和慢性鼻窦炎(CRS)人群的鼻窦菌群中都普遍存在5个核心菌属:棒状杆菌、葡萄球菌、链球菌、嗜血杆菌和莫拉菌;
  • 棒状杆菌和葡萄球菌在大多数人中是优势菌属,鼻息肉CRS患者中棒状杆菌的相对丰度显著降低;
  • 这种核心菌群特征存在于不同国家和疾病表型(哮喘、糖尿病等)的人群中。
主编推荐语
mildbreeze
《Allergy》近期发表了一项多国合作研究,分析了来自9个国家14个中心共410名受试者的鼻窦菌群组成,鉴定出普遍存在的5个核心菌属,分析了菌群组成与疾病之间的潜在关联。
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The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology

国际鼻窦微生物组研究:鼻窦细菌生态学的多中心、跨国特征

10.1111/all.14276

03-13, Article

Abstract & Authors:展开

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The sinonasal microbiome remains poorly defined, with our current knowledge based on a few cohort studies whose findings are inconsistent. Furthermore, the variability of the sinus microbiome across geographical divides remains unexplored. We characterize the sinonasal microbiome and its geographical variations in both health and disease using 16S rRNA gene sequencing of 410 individuals from across the world. Although the sinus microbial ecology is highly variable between individuals, we identify a core microbiome comprised of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus and Moraxella species in both healthy and chronic rhinosinusitis (CRS) cohorts. Corynebacterium (mean relative abundance = 44.02%) and Staphylococcus (mean relative abundance = 27.34%) appear particularly dominant in the majority of patients sampled. Amongst patients suffering from CRS with nasal polyps, a statistically significant reduction in relative abundance of Corynebacterium (40.29% vs 50.43%; P = .02) was identified. Despite some measured differences in microbiome composition and diversity between some of the participating centres in our cohort, these differences would not alter the general pattern of core organisms described. Nevertheless, atypical or unusual organisms reported in short-read amplicon sequencing studies and that are not part of the core microbiome should be interpreted with caution. The delineation of the sinonasal microbiome and standardized methodology described within our study will enable further characterization and translational application of the sinus microbiota.

First Authors:
Sathish Paramasivan

Correspondence Authors:
Alkis J Psaltis

All Authors:
Sathish Paramasivan,Ahmed Bassiouni,Arron Shiffer,Matthew R Dillon,Emily K Cope,Clare Cooksley,Mahnaz Ramezanpour,Sophia Moraitis,Mohammad Javed Ali,Benjamin Bleier,Claudio Callejas,Marjolein E Cornet,Richard G Douglas,Daniel Dutra,Christos Georgalas,Richard J Harvey,Peter H Hwang,Amber U Luong,Rodney J Schlosser,Pongsakorn Tantilipikorn,Marc A Tewfik,Sarah Vreugde,Peter-John Wormald,J Gregory Caporaso,Alkis J Psaltis

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