印遇龙等:产肠道毒素大肠杆菌如何促进感染和菌群失衡?
  • 产肠道毒素的大肠杆菌(ETEC)感染诱导肠道IL-17的表达及肠道菌群的失调;
  • 并增加了能够产生γ-氨基丁酸的乳酸乳球菌的丰度;
  • 在ETEC感染小鼠中使用抗生素,可降低肠道IL-17的表达,而γ-氨基丁酸或乳酸乳球菌可恢复肠道IL-17的表达;
  • γ-氨基丁酸通过活化mTORC1-S6K1信号通路以提高肠道IL-17的表达。
#魏泓教授团队研究成果集#
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蓝灿辉 | 热心肠先生
关于产肠道毒素的大肠杆菌(ETEC)感染诱导肠道IL-17的表达及肠道菌群的失调的研究,推荐阅读。
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Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection

在产肠道毒素大肠杆菌(ETEC)感染期间肠道菌群产生的GABA介导IL-17表达

10.3389/fimmu.2016.00685

2017-01-16, Article

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Intestinal microbiota has critical importance in pathogenesis of intestinal infection; however, the role of intestinal microbiota in intestinal immunity during enterotoxigenic Escherichia coli (ETEC) infection is poorly understood. The present study tested the hypothesis that the intestinal microbiota is associated with intestinal interleukin-17 (IL-17) expression in response to ETEC infection. Here, we found ETEC infection induced expression of intestinal IL-17 and dysbiosis of intestinal microbiota, increasing abundance of γ-aminobutyric acid (GABA)-producing Lactococcus lactis subsp. lactis. Antibiotics treatment in mice lowered the expression of intestinal IL-17 during ETEC infection, while GABA or L. lactis subsp. lactis administration restored the expression of intestinal IL-17. L. lactis subsp. lactis administration also promoted expression of intestinal IL-17 in germ-free mice during ETEC infection. GABA enhanced intestinal IL-17 expression in the context of ETEC infection through activating mechanistic target of rapamycin complex 1 (mTORC1)-ribosomal protein S6 kinase 1 (S6K1) signaling. GABA-mTORC1 signaling also affected intestinal IL-17 expression in response to Citrobacter rodentium infection and in drug-induced model of intestinal inflammation. These findings highlight the importance of intestinal GABA signaling in intestinal IL-17 expression during intestinal infection and indicate the potential of intestinal microbiota-GABA signaling in IL-17-associated intestinal diseases.

First Authors:
Wenkai Ren

Correspondence Authors:
Bie Tan,Tiejun Li,Yulong Yin

All Authors:
Wenkai Ren,Jie Yin,Hao Xiao,Shuai Chen,Gang Liu,Bie Tan,Nengzhang Li,Yuanyi Peng,Tiejun Li,Benhua Zeng,Wenxia Li,Hong Wei,Zhinan Yin,Guoyao Wu,Philip R Hardwidge,Yulong Yin

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