吃全谷黑麦后,哪些代谢物发生改变?
创作:迟卉 审核:mildbreeze 2019年05月21日
  • 一项随机交叉试验中15名成人分组,吃白面包(WW)4周后,分别吃4周全黑麦面包(WGR)或富含发酵黑麦麸的白面包(WW+RB),之后交换,分析血浆代谢物;
  • 5种内源代谢物和15种黑麦植物化学物质与WGR摄入相关;
  • WGR期后,血浆5-羟色胺、牛磺酸和甘油磷酸胆碱的浓度显著低于WW期;
  • 与WW+RB相比,吃WGR后有2种缩醛磷脂酰乙醇胺的浓度降低;
  • 高脂饮食小鼠喂养实验中,与纤维素相比,补充黑麦麸或小麦糊粉的小鼠结肠组织5-羟色胺浓度显著降低。
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mildbreeze
有研究显示,吃全谷黑麦有一定健康益处。《The American Journal of Clinical Nutrition》近期发表一项人体和动物研究表明,吃全谷黑麦可降低肠道和血液中的5-羟色胺水平。
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Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

食用全谷黑麦后,健康成人血浆5-羟色胺的降低和其他代谢物的变化:一项非靶向代谢组学研究

10.1093/ajcn/nqy394

2019-04-27, Article

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Background: Wholegrain consumption has been associated with beneficial health effects including reduction of diabetes and cancer risk; however, the underlying mechanisms are not fully understood.
Objective: The aim of this study was to characterize the effects of wholegrain rye intake on circulating metabolites in a human intervention study using untargeted metabolomics.
Methods: The intervention consisted of 2 successive 4-wk periods in a randomized crossover design, where 15 adults consumed wholegrain rye bread (WGR) or white wheat bread enriched with fermented rye bran (WW+RB), following a 4-wk rye-free period with white wheat bread (WW). Fasting plasma samples were collected at the end of each period and analyzed using liquid chromatography-mass spectrometry. Metabolic profiles were compared to identify compounds discriminating WGR from the WW+RB and WW periods. Because peripheral serotonin is produced mainly in the gut, a hypothesis of its altered biosynthesis as a response to increased cereal fiber intake was tested by measuring intestinal serotonin of mice fed for 9 wk on a high-fat diet supplemented with different sources of fiber (rye bran flour, ground wheat aleurone, or powdered cellulose).
Results: Five endogenous metabolites and 15 rye phytochemicals associated with WGR intake were identified. Plasma concentrations of serotonin, taurine, and glycerophosphocholine were significantly lower after the WGR than WW period (Q < 0.05). Concentrations of 2 phosphatidylethanolamine plasmalogens, PE(18:2/P-18:0) and PE(18:2/P-16:0), were lower after the WGR period than the WW+RB period (Q < 0.05). The concentration of serotonin was significantly lower in the colonic tissue of mice that consumed rye bran or wheat aleurone compared with cellulose (P < 0.001).
Conclusions: Wholegrain rye intake decreases plasma serotonin in healthy adults when compared with refined wheat. Intake of rye bran and wheat aleurone decreases colonic serotonin in mice. These results suggest that peripheral serotonin could be a potential link between wholegrain consumption and its associated health effects.

First Authors:
Pekka Keski-Rahkonen,Marc J Gunter,Augustin Scalbert

Correspondence Authors:
Pekka Keski-Rahkonen

All Authors:
Pekka Keski-Rahkonen,Marjukka Kolehmainen,Jenni Lappi,Valérie Micard,Jenna Jokkala,Natalia Rosa-Sibakov,Jussi Pihlajamäki,Pirkka V Kirjavainen,Hannu Mykkänen,Kaisa Poutanen,Marc J Gunter,Augustin Scalbert,Kati Hanhineva

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