• 一溃疡性结肠炎患者让自己感染毛首鞭形线虫,研究其肠道粘膜细胞和分子动态变化;
  • 疾病得到缓解,生成IL-22并促粘膜修复的T细胞富集;
  • 寄生虫定殖区域,糖和脂代谢相关基因上调;结肠炎活跃区域,促炎症基因上调;
  • 症状减轻可能与2型辅助T细胞因子和IL-22引起的杯状细胞增生、粘液产生有关。
蓝灿辉 | 热心肠先生

IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient



2010-12-02, Article

Abstract & Authors:展开

Ulcerative colitis, a type of inflammatory bowel disease, is less common in countries endemic for helminth infections, suggesting that helminth colonization may have the potential to regulate intestinal inflammation in inflammatory bowel diseases. Indeed, therapeutic effects of experimental helminth infection have been reported in both animal models and clinical trials. Here, we provide a comprehensive cellular and molecular portrait of dynamic changes in the intestinal mucosa of an individual who infected himself with Trichuris trichiura to treat his symptoms of ulcerative colitis. Tissue with active colitis had a prominent population of mucosal T helper (T(H)) cells that produced the inflammatory cytokine interleukin-17 (IL-17) but not IL-22, a cytokine involved in mucosal healing. After helminth exposure, the disease went into remission, and IL-22-producing T(H) cells accumulated in the mucosa. Genes involved in carbohydrate and lipid metabolism were up-regulated in helminth-colonized tissue, whereas tissues with active colitis showed up-regulation of proinflammatory genes such as IL-17, IL-13RA2, and CHI3L1. Therefore, T. trichiura colonization of the intestine may reduce symptomatic colitis by promoting goblet cell hyperplasia and mucus production through T(H)2 cytokines and IL-22. Improved understanding of the physiological effects of helminth infection may lead to new therapies for inflammatory bowel diseases.

First Authors:
Mara J Broadhurst,Jacqueline M Leung

Correspondence Authors:
P'ng Loke

All Authors:
Mara J Broadhurst,Jacqueline M Leung,Vikram Kashyap,Joseph M McCune,Uma Mahadevan,James H McKerrow,P'ng Loke