秦环龙团队:菌群失调与大肠癌相关
  • 人体肠道菌群失调与散发性结肠直肠癌(CRC)相关;
  • 对CRC患者的近端及末端的癌组织及正常癌旁组织的菌群进行分析;
  • CRC患者与健康人的菌群结构显著不同,CRC患者的厚壁菌门及梭菌属增加,而变形菌门减少;
  • 相比于正常癌旁组织,癌组织的乳球菌属及梭菌属丰度较高,假单胞菌属及埃希氏杆菌属-志贺氏杆菌属丰度降低。
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蓝灿辉 | 热心肠先生
这是同济大学第十人民医院秦环龙教授和团队的最新研究,强烈推荐阅读参考。
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Microbiota disbiosis is associated with colorectal cancer

菌群失调与结肠直肠癌相关

10.3389/fmicb.2015.00020

2015-02-02, Article

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The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent non-cancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for CRC.

First Authors:
Zhiguang Gao,Bomin Guo,Renyuan Gao

Correspondence Authors:
Huanlong Qin

All Authors:
Zhiguang Gao,Bomin Guo,Renyuan Gao,Qingchao Zhu,Huanlong Qin

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