创作:szx 审核:szx 2018年01月01日
  • 小鼠分为2组,1组自由进食,另1组喂食等卡路里的食物,但每日仅在2个时间段进食(ITAD);
  • ITAD进食方式改变了小鼠的节律性自噬及葡萄糖/脂质代谢,后者与进食方式驱动的循环胰岛素改变相关;
  • ITAD进食方式减少了肥胖的发生,但增加了肌肉质量(不同于卡路里限制);
  • ITAD进食方式促进能量消耗,降低脂质水平,抑制糖异生,防止年龄/肥胖相关的代谢缺陷;
  • ITAD进食方式改变了肝脏、脂肪组织、肌原、阿黑皮素原神经元特异性自噬。
蓝灿辉 | 热心肠先生
这是Cell Metabolism[IF:18.164]近期发表的重要研究,发现在同等热量摄入情况下,一天只吃两顿让小鼠不易产生肥胖,并防止代谢缺陷。动物实验,对人身上的研究有启发意义,或许很快我们可以看到人类志愿者身上的类似研究。
Cell Metabolism [IF:21.567]

System-wide Benefits of Intermeal Fasting by Autophagy



2017-10-26, Article

Abstract & Authors:展开

Autophagy failure is associated with metabolic insufficiency. Although caloric restriction (CR) extends healthspan, its adherence in humans is poor. We established an isocaloric twice-a-day (ITAD) feeding model wherein ITAD-fed mice consume the same food amount as ad libitum controls but at two short windows early and late in the diurnal cycle. We hypothesized that ITAD feeding will provide two intervals of intermeal fasting per circadian period and induce autophagy. We show that ITAD feeding modifies circadian autophagy and glucose/lipid metabolism that correlate with feeding-driven changes in circulating insulin. ITAD feeding decreases adiposity and, unlike CR, enhances muscle mass. ITAD feeding drives energy expenditure, lowers lipid levels, suppresses gluconeogenesis, and prevents age/obesity-associated metabolic defects. Using liver-, adipose-, myogenic-, and proopiomelanocortin neuron-specific autophagy-null mice, we mapped the contribution of tissue-specific autophagy to system-wide benefits of ITAD feeding. Our studies suggest that consuming two meals a day without CR could prevent the metabolic syndrome.

First Authors:
Nuria Martinez-Lopez,Elena Tarabra

Correspondence Authors:
Rajat Singh

All Authors:
Nuria Martinez-Lopez,Elena Tarabra,Miriam Toledo,Marina Garcia-Macia,Srabani Sahu,Luisa Coletto,Ana Batista-Gonzalez,Nir Barzilai,Jeffrey E Pessin,Gary J Schwartz,Sander Kersten,Rajat Singh