第三军医大学庄园:幽门螺杆菌如何促进胃部细菌定殖及胃炎
创作:女巫 审核:szx 2019年04月10日
  • 基质金属蛋白酶-10(MMP-10)在胃粘膜中上调,由幽门螺旋杆菌和IL-22协同诱导胃上皮细胞通过ERK途径产生;
  • 人胃MMP-10与幽门螺旋杆菌(Hp)定殖和胃炎的严重程度相关,小鼠非骨髓来源细胞的MMP-10促进细菌定殖和炎症;
  • IL-22−/−、MMP-10−/−和IL-22−/−MMP-10−/−小鼠中Hp定殖和炎症减弱;
  • MMP-10相关炎症的特征是由胃上皮细胞通过MMP-10-CXCL16轴介导的CD8+T细胞的流入;
  • MMP-10减少Reg3a等蛋白,损伤宿主防御并增加Hp定殖。
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来自第三军医大学庄园团队在Science advances上发表的一项最新研究,发现幽门螺旋杆菌定殖可促进胃上皮细胞产生基质金属蛋白酶-10(MMP-10),后者可促进细菌的定殖并加剧胃炎。
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Science advances [IF:13.116]

Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis

幽门螺旋杆菌诱导的基质金属蛋白酶-10促进胃细菌定殖和胃炎

10.1126/sciadv.aau6547

2019-04-03, Article

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The interaction between gastric epithelium and immune response plays key roles in H. pylori–associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in H. pylori infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by H. pylori and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with H. pylori colonization and the severity of gastritis, and mouse MMP-10 from non–BM-derived cells promoted bacteria colonization and inflammation. H. pylori colonization and inflammation were attenuated in IL-22−/−, MMP-10−/−, and IL-22−/−MMP-10−/− mice. MMP-10–associated inflammation is characterized by the influx of CD8+ T cells, whose migration is induced via MMP-10–CXCL16 axis by gastric epithelial cells. Under the influence of MMP-10, Reg3a, E-cadherin, and zonula occludens–1 proteins decrease, resulting in impaired host defense and increased H. pylori colonization. Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis.

First Authors:
Yi-pin Lv,Ping Cheng

Correspondence Authors:
Yuan Zhuang

All Authors:
Yi-pin Lv,Ping Cheng,Jin-yu Zhang,Fang-yuan Mao,Yong-sheng Teng,Yu-gang Liu,Hui Kong,Xiao-long Wu,Chuan-jie Hao,Bin Han,Qiang Ma,Shi-ming Yang,Weisan Chen,Liu-sheng Peng,Ting-ting Wang,Quan-ming Zou,Yuan Zhuang

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