中南大学团队:YAP1促大肠癌新机制
创作:爱的抉择 审核:Lexi 2020年02月24日
  • YAP1是一种转录共激活因子,促进肿瘤发生,但YAP1如何调控肿瘤中lncRNA仍不清楚;
  • YAP1靶基因——长非编码RNA LINC00152——在人结直肠癌(CRC)组织中高表达,且YAP1在转录水平调控LINC00152表达;
  • 体内外实验证实LINC00152在CRC中具有致癌作用;
  • LINC00152作为内源性RNA,与miR-632、miR-185-3p形成竞争关系,调控FSCN1的表达,从而促进CRC的恶性增殖和转移;
  • 靶向YAP1/LINC00152/FSCN1能抑制CRC进展。
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Lexi
作为一种转录辅助激活因子,Yes相关蛋白1 (YAP1)在肿瘤发生中的作用已被证实。然而,YAP1调节的长链非编码RNA(lncRNA)在肿瘤中的作用机制尚不清楚。来自中南大学的马健和Xiayu Li研究团队最新发表在Advanced Science的研究发现YAP1相关性长非编码RNA LINC00152在人结直肠癌(CRC)组织中高表达,具有致癌作用,而YAP1在转录水平调控LINC00152表达。机制上,LINC00152作为内源性RNA,与miR-632、miR-185-3p形成竞争关系,调控FSCN1的表达,从而促进CRC的恶性增殖和转移。这一发现为CRC中的“YAP1-lncRNA”提供了一种新的调控模式,从而产生了一个新的“YAP1/LINC00152/miR‐632‐miR‐185‐3p/FSCN1”视角,以探索CRC中YAP1的促癌机制。
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Advanced Science [IF:16.806]

Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer

靶向YAP1/LINC00152/FSCN1信号通路预防结直肠癌进展

10.1002/advs.201901380

2019-12-05, Article

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As a transcription coactivator, Yes‐associated protein 1 (YAP1)'s role in tumorigenesis is well established. However, the mechanism of YAP1‐regulating long noncoding RNAs (lncRNA) in tumors is still largely unknown. Here, a YAP1 target gene, long intergenic noncoding RNA 00152 (LINC00152), which is highly expressed in colorectal cancer (CRC), is identified. The oncogenic functions of LINC00152 in CRC are demonstrated by a panel of in vitro and in vivo experiments. Further studies reveal the potential downstream mechanisms of LINC00152, which can act as a competing endogenous RNA sponging with miR‐632 and miR‐185‐3p to regulate Fascin actin‐bundling protein 1 (FSCN1) expression and thus promote the malignant proliferation and metastasis in CRC cells. Targeting the YAP1/LINC00152/FSCN1 axis inhibits the progression of CRC. This finding provides a new regulatory model of the “YAP1‐lncRNA” in CRC, which gives rise to a new perspective, “YAP1/LINC00152/miR‐632‐miR‐185‐3p/FSCN1,” to explore the cancer‐promoting mechanism of YAP1 involved in CRC.

First Authors:
Chunlin Ou

Correspondence Authors:
Xiayu Li,Jian Ma

All Authors:
Chunlin Ou,Zhenqiang Sun,Xiaoyun He,Xiaoling Li,Songqing Fan,Xiang Zheng,Qiu Peng,Guiyuan Li,Xiayu Li,Jian Ma

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