浙江中医药大学:灵芝多糖调节菌群以抑制小鼠的食源性肥胖
创作:szx 审核:szx 01月28日
  • 从破壁灵芝孢子粉中提取的多糖(BSGLP)可抑制高脂饮食诱导的小鼠肥胖、高脂血症、脂肪积累,减少脂肪组织中的巨噬细胞浸润,并缓解炎症;
  • BSGLP可改善高脂饮食引起的小鼠肠道菌群失调,维持肠道屏障功能,增加粪便短链脂肪酸水平,上调白色脂肪组织中的GPR43表达,并缓解内毒素血症;
  • 粪菌移植实验证实了BSGLP通过调节肠道菌群发挥上述作用;
  • 机制上,BSGLP可缓解高脂饮食诱导的脂肪组织中的TLR4/Myd88/NF-κB信号通路上调。
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szx
灵芝被发现具有抗肥胖作用。浙江中医药大学的王兴亚团队在Carbohydrate Polymers上发表的一项最新研究,发现从破壁灵芝孢子粉中提取的多糖可通过调节肠道菌群,缓解高脂饮食诱导的小鼠肥胖、高脂血症及炎症。
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Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

破壁灵芝孢子粉中的多糖通过调节肠道菌群抑制肥胖及炎症

10.1016/j.carbpol.2020.117594

01-04, Article

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Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against obesity and its underlying mechanisms have never been reported. In the current study, we showed that BSGLP inhibited high-fat diet (HFD)-induced obesity, hyperlipidemia, inflammation, and fat accumulation in C57BL/6 J mice. BSGLP improved HFD-induced gut microbiota dysbiosis, maintained intestinal barrier function, increased short-chain fatty acids production and GPR43 expression, ameliorated endotoxemia, manifested by reduced serum lipopolysaccharide level, and increased ileum expression of tight junction proteins and antimicrobial peptides. Fecal microbiota transplantation study confirmed that BSGLP-induced microbiota change is responsible, at least in part, for obesity inhibition. Besides, BSGLP notably alleviated HFD-induced upregulation of TLR4/Myd88/NF-κB signaling pathway in adipose tissue. Collectively, our study showed for the first time that BSGLP might be used as a prebiotic agent to inhibit obesity and hyperlipidemia through modulating inflammation, gut microbiota, and gut barrier function.

First Authors:
Tingting Sang,Chengjie Guo

Correspondence Authors:
Xingya Wang

All Authors:
Tingting Sang,Chengjie Guo,Dandan Guo,Jianjun Wu,Yujie Wang,Ying Wang,Jiajun Chen,Chaojie Chen,Kaikai Wu,Kun Na,Kang Li,Liu Fang,Cuiling Guo,Xingya Wang

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