长链ω-3脂肪酸或不能有效缓解抑郁和焦虑症
创作:兵兵 审核:兵兵 2019年11月10日
  • 本综述涉及31项长链ω-3脂肪酸,一项α亚麻酸以及一项总多不饱和脂肪研究,不涉及ω-6相关研究;
  • 分析结果显示,增加长链ω-3脂肪酸对抑郁和焦虑症有非常小或者没有影响;
  • 而它们对于抑郁症严重程度,以及对已有抑郁症状的缓解作用,则缺乏相应的研究证据;
  • 研究结果不受误差、ω-3剂量、持续时间以及营养素的影响;
  • 长达40个月以上的α亚麻酸摄入(2克/天)还可能非常轻微地增加抑郁风险;
  • 长链ω-3脂肪酸或无法有效预防抑郁和焦虑症。
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兵兵
本文共综述了34项关于多不饱和脂肪酸与焦虑和抑郁的相关研究,其中32项时关于ω-3脂肪酸。基于以上研究的分析结果显示,单纯增加长链ω-3脂肪酸几乎对抑郁和焦虑症状没有影响。
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Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials

ω-3以及其他多不饱和脂肪酸抑制抑郁和焦虑症:系统综述和随机试验的荟萃分析

10.1192/bjp.2019.234

2019-10-24, Review

Abstract & Authors:展开

Abstract:收起
Background: There is strong public belief that polyunsaturated fats protect against and ameliorate depression and anxiety.
Aims: To assess effects of increasing omega-3, omega-6 or total polyunsaturated fat on prevention and treatment of depression and anxiety symptoms.
Method: We searched widely (Central, Medline and EMBASE to April 2017, trial registers to September 2016, ongoing trials updated to August 2019), including trials of adults with or without depression or anxiety, randomised to increased omega-3, omega-6 or total polyunsaturated fat for ≥24 weeks, excluding multifactorial interventions. Inclusion, data extraction and risk of bias were assessed independently in duplicate, and authors contacted for further data. We used random-effects meta-analysis, sensitivity analyses, subgrouping and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) assessment.
Results: We included 31 trials assessing effects of long-chain omega-3 (n = 41 470), one of alpha-linolenic acid (n = 4837), one of total polyunsaturated fat (n = 4997) and none of omega-6. Meta-analysis suggested that increasing long-chain omega-3 probably has little or no effect on risk of depression symptoms (risk ratio 1.01, 95% CI 0.92–1.10, I2 = 0%, median dose 0.95 g/d, duration 12 months) or anxiety symptoms (standardised mean difference 0.15, 95% CI 0.05–0.26, I2 = 0%, median dose 1.1 g/d, duration 6 months; both moderate-quality evidence). Evidence of effects on depression severity and remission in existing depression were unclear (very-low-quality evidence). Results did not differ by risk of bias, omega-3 dose, duration or nutrients replaced. Increasing alpha-linolenic acid by 2 g/d may increase risk of depression symptoms very slightly over 40 months (number needed to harm, 1000).
Conclusions: Long-chain omega-3 supplementation probably has little or no effect in preventing depression or anxiety symptoms.
Declaration of interest: L.H. and A.A. were funded to attend the World Health Organization Nutrition Guidance Expert Advisory Group (NUGAG) Subgroup on Diet and Health meetings and present review results. The authors report no other conflicts of interest.

First Authors:
Katherine H O Deane

Correspondence Authors:
Lee Hooper

All Authors:
Katherine H O Deane,Oluseyi F Jimoh,Priti Biswas,Alex O'Brien,Sarah Hanson,Asmaa S Abdelhamid,Chris Fox,Lee Hooper

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