江南大学:补充油酸可降低C-反应蛋白
创作:szx 审核:szx 2020年12月27日
  • 对31项RCT研究(共涉及1634名受试者,干预至少持续4周)进行荟萃分析,总结补充油酸对成年人血液炎症因子的影响;
  • 11项RCT涉及健康人、其它RCT涉及2型糖尿病、高胆固醇血症、高脂血症等疾病的患者;
  • 油酸摄入增加可显著降低C-反应蛋白的水平,但对TNF、IL-6、纤维蛋白原、1型纤溶酶原激活抑制剂(PAI-1)活性、可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞间粘附分子-1(sVCAM-1)的水平无显著影响。
主编推荐语
szx
油酸是一种典型的单不饱和脂肪酸,在橄榄油、菜籽油等蔬菜油中有较高含量。江南大学的王兴国团队在Critical Reviews in Food Science and Nutrition上发表的一项荟萃分析结果,总结了31项RCT研究(共涉及1634名成年受试者)的数据后发现,补充油酸可显著降低C-反应蛋白的水平,但对TNF、IL-6等其它炎症因子无显著影响。
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Dietary oleic acid supplementation and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials

膳食油酸补充及血液炎症因子:对随机对照试验的系统性综述与荟萃分析

10.1080/10408398.2020.1854673

2020-12-11, Review

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The aim of this systematic review and meta-analysis was to analyze data from randomized controlled trials (RCTs) assessing the effects of oleic acid (OA) supplementation on blood inflammatory markers in adults. PubMed, EMBASE and Cochrane Library databases were systematically searched from 1950 to 2019, with adults and a minimum intervention duration of 4 weeks. The effect size was estimated, adopting standardized mean difference (SMD) and 95% confidence interval (CI). Of the 719 identified studies, thirty-one RCTs involving 1634 subjects were eligible. The results of this study revealed that increasing OA supplementation significantly reduced C-reactive protein (CRP) (SMD: −0.11, 95% CI: −0.21, −0.01, P = 0.038). However, dietary OA consumption did not significantly affect tumor necrosis factor (TNF) (SMD: −0.05, 95% CI: −0.19, 0.10, P = 0.534), interleukin 6 (IL-6) (SMD: 0.01, 95% CI: −0.10, 0.13, P = 0.849), fibrinogen (SMD: 0.08, 95% CI: −0.16, 0.31, P = 0.520), plasminogen activator inhibitor type 1 (PAI-1) activity (SMD: −0.11, 95% CI: −0.34, 0.12, P = 0.355), soluble intercellular adhesion molecule-1 (sICAM-1) (SMD: −0.06, 95% CI: −0.26, 0.13, P = 0.595) or soluble vascular cell adhesion molecule-1 (sVCAM-1) (SMD: −0.04, 95% CI: −0.27, 0.18, P = 0.701). Overall, the meta-analysis demonstrated that dietary OA supplementation significantly reduced CRP, yet did not affect other inflammatory markers including TNF, IL-6, fibrinogen, PAI-1 activity, sICAM-1or sVCAM-1.

First Authors:
Qiong Wang

Correspondence Authors:
Xingguo Wang

All Authors:
Qiong Wang,Ruijie Liu,Ming Chang,Hui Zhang,Qingzhe Jin,Xingguo Wang

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