中科院动物所+延边大学:人参提取物的肠球菌代谢物,或是减肥新思路
  • 人参提取物(GE)具有抗肥胖作用,给肥胖小鼠灌胃GE,可改变肠道菌群组成,使粪肠球菌增多;
  • 粪肠球菌及其代谢物肉豆蔻油酸(MA,一种不饱和长链脂肪酸),可通过增加能量代谢、活化褐色脂肪组织、促进米色脂肪形成,来减少小鼠肥胖和脂肪肝;
  • 粪肠球菌编码的酰基辅酶A硫酯酶(ACOT)可能介导了MA的生物合成,敲低ACOT基因可显著减少粪肠球菌的MA生成,从而使其丧失上述对代谢的有益效果。
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人参提取物被报道有抗肥胖的作用,Gut最新发表了中科院动物所金万洙和延边大学李东浩与团队的研究,揭示了这一现象背后的肠道菌群机制,表明人参提取物可富集肠道内的粪肠球菌,这种菌通过酰基辅酶A硫酯酶产生的肉豆蔻油酸(一种不饱和长链脂肪酸)激活褐色脂肪组织,从而帮小鼠抵抗肥胖。这些发现说明,除了短链脂肪酸,菌群产生的特定长链脂肪酸也有益于代谢健康,这为研发新型抗肥胖药物提供了新思路。
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Gut [IF:17.943]

Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation

肠球菌产生的肉豆蔻油酸通过激活褐色脂肪组织来减少肥胖

10.1136/gutjnl-2019-319114

2019-11-19, Article

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Objective : Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by gut microbiota. Ginseng has been reported to aid in body weight management, however, its mechanism of action is not yet clear. In this study, we focused on the potential modulating effect of ginseng on gut microbiota, aiming to identify specific strains and their metabolites, especially long-chain fatty acids (LCFA), which mediate the anti-obesity effects of ginseng.
Design : Db/db mice were gavaged with ginseng extract (GE) and the effects of GE on gut microbiota were evaluated using 16S rDNA-based high throughput sequencing. To confirm the candidate fatty acids, untargeted metabolomics analyses of the serum and medium samples were performed.
Results : We demonstrated that GE can induce Enterococcus faecalis, which can produce an unsaturated LCFA, myristoleic acid (MA). Our results indicate that E. faecalis and its metabolite MA can reduce adiposity by brown adipose tissue (BAT) activation and beige fat formation. In addition, the gene of E. faecalis encoding Acyl-CoA thioesterases (ACOTs) exhibited the biosynthetic potential to synthesise MA, as knockdown (KD) of the ACOT gene by CRISPR-dCas9 significantly reduced MA production. Furthermore, exogenous treatment with KD E. faecalis could not reproduce the beneficial effects of wild type E. faecalis, which work by augmenting the circulating MA levels.
Conclusions: Our results demonstrated that the gut microbiota-LCFA-BAT axis plays an important role in host metabolism, which may provide a strategic advantage for the next generation of anti-obesity drug development.

First Authors:
LinHu Quan

Correspondence Authors:
Wanzhu Jin

All Authors:
LinHu Quan,Chuanhai Zhang,Meng Dong,Jun Jiang,Hongde Xu,Chunlong Yan,Xiaomeng Liu,Huiqiao Zhou,Hanlin Zhang,Li Chen,FeiLiang Zhong,Zhao-Bo Luo,Sin Man Lam,Guanghou Shui,Donghao Li,Wanzhu Jin

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